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lüll Role of ubiquitylation in cellular membrane transport Staub O; Rotin DPhysiol Rev 2006[Apr]; 86 (2): 669-707Ubiquitylation of membrane proteins has gained considerable interest in recent years. It has been recognized as a signal that negatively regulates the cell surface expression of many plasma membrane proteins both in yeast and in mammalian cells. Moreover, it is also involved in endoplasmic reticulum-associated degradation of membrane proteins, and it acts as a sorting signal both in the secretory pathway and in endosomes, where it targets proteins into multivesicular bodies in the lumen of vacuoles/lysosomes. In this review we discuss the progress in understanding these processes, achieved during the past several years.|Animals[MESH]|Biological Transport/physiology[MESH]|Cell Membrane/*metabolism[MESH]|Humans[MESH]|Membrane Proteins/metabolism[MESH]|Ubiquitin-Protein Ligase Complexes/metabolism[MESH]|Ubiquitins/*metabolism[MESH]|Yeasts/metabolism[MESH] |