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Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways Capili AD; Lima CDCurr Opin Struct Biol 2007[Dec]; 17 (6): 726-35Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, highlighting essential steps during Ub/Ubl modification that illustrate common and divergent mechanistic themes within this important process.|Models, Molecular[MESH]|Protein Conformation[MESH]|Ubiquitin/chemistry/*metabolism[MESH] |
