Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Strategies for the identification of ubiquitin ligase inhibitors Goldenberg SJ; Marblestone JG; Mattern MR; Nicholson BBiochem Soc Trans 2010[Feb]; 38 (Pt 1): 132-6Dysregulation of the UPS (ubiquitin-proteasome system) has been implicated in a wide range of pathologies including cancer, neurodegeneration and viral infection. Inhibiting the proteasome has been shown to be an effective therapeutic strategy in humans; however, toxicity with this target remains high. E3s (Ub-protein ligases) represent an alternative attractive therapeutic target in the UPS. In this paper, we will discuss current platforms that report on E3 ligase activity and can detect E3 inhibitors, and underline the advantages and disadvantages of each approach.|*Proteasome Inhibitors[MESH]|Biological Assay/methods[MESH]|Humans[MESH]|Immune System Diseases/drug therapy/enzymology[MESH]|Neoplasms/drug therapy/enzymology[MESH]|Neurodegenerative Diseases/drug therapy/enzymology[MESH]|Protease Inhibitors/*metabolism[MESH]|Proteasome Endopeptidase Complex/metabolism[MESH]|Ubiquitin-Protein Ligases/*antagonists & inhibitors/metabolism[MESH]|Ubiquitin/*metabolism[MESH] |