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Sirtuin
LE WE PMID CA
Sirtuin2549Sirtuin

14 3 3

Alzheimer s disease

AMP activated protein kinase

BMAL1

Circadian clock

DAF16

DNA (Repair and Toxicology)

Heterochromatin island hypothesis

Histone deacetylase

Long life

Mitochondria (BASKET)

NAD

Neoplasia (Tumor biology and immunology)

Nicotinamide phosphoribosyltransferase

PER2

Rpd3 Hda1 protein family

Sirt3

SIRT4

SIRT5

Sirtuin

Vorinostat ttHDAC

2006  
1
Neuronal protection by sirtuins in Alzheimer's disease.
[16219030] J Neurochem 96(2): 305-13 (2006)
2008  
2
SIRT1: roles in aging and cancer.
[19017485] BMB Rep 41(11): 751-6 (2008)
2009  
3
SIRT1, is it a tumor promoter or tumor suppressor?
[19173036] Int J Biol Sci 5(2): 147-52 (2009)
2009  
4
The conserved role of sirtuins in chromatin regulation.
[19378253] Int J Dev Biol 53(2-3): 303-22 (2009)
2008  
5
Mechanisms and molecular probes of sirtuins.
[18940661] Chem Biol 15(10): 1002-13 (2008)
2007  
6
Sirtuins in mammals: insights into their biological function.
[17447894] Biochem J 404(1): 1-13 (2007)
2008  
7
Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.
[18340017] Circ Res 102(5): 519-28 (2008)
2004  
8
Sir-viving cardiac stress: cardioprotection mediated by a longevity gene.
[15539638] Circ Res 95(10): 953-6 (2004)
2005  
9
Small molecule regulation of Sir2 protein deacetylases.
[16156783] FEBS J 272(18): 4607-16 (2005)
2008  
10
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.
[18036349] FEBS Lett 582(1): 46-53 (2008)
2006  
11
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.
[17079682] Genes Dev 20(21): 2913-21 (2006)
2003  
12
How does calorie restriction work?
[12569120] Genes Dev 17(3): 313-21 (2003)
2000  
13
Sir2 links chromatin silencing, metabolism, and aging.
[10809662] Genes Dev 14(9): 1021-6 (2000)
2004  
14
Sirtuins: Sir2-related NAD-dependent protein deacetylases.
[15128440] Genome Biol 5(5): 224 (2004)
2008  
15
Acetylation in nuclear receptor signaling and the role of sirtuins.
[18165438] Mol Endocrinol 22(3): 539-45 (2008)
2007  
16
Sirtuin functions in health and disease.
[17456799] Mol Endocrinol 21(8): 1745-55 (2007)
2000  
17
The Sir2 protein family: A novel deacetylase for gene silencing and more.
[11114164] Proc Natl Acad Sci U S A 97(26): 14030-2 (2000)
1999  
18
Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality.
[10630591] Toxicol Sci 52(2 Suppl): 56-60 (1999)
2006  
19
Sirtuins in aging and age-related disease.
[16873059] Cell 126(2): 257-68 (2006)
2005  
20
Calorie restriction--the SIR2 connection.
[15734680] Cell 120(4): 473-82 (2005)
2008  
21
Conserved metabolic regulatory functions of sirtuins.
[18249170] Cell Metab 7(2): 104-12 (2008)
2005  
22
Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds.
[15862287] FEBS Lett 579(12): 2541-5 (2005)
2011  
23
Identification of specific and semi-specific SIRT inhibitors through computer-aided studies.
[21937768] Aging (Albany NY) 3(9): 819-20 (2011)
2011  
24
Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair.
[21946623] Aging (Albany NY) 3(9): 829-35 (2011)
2011  
25
Does hypothalamic SIRT1 regulate aging?
[21464518] Aging (Albany NY) 3(3): 325-8 (2011)
2011  
26
Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis.
[21483037] Aging (Albany NY) 3(4): 444-9 (2011)
2010  
27
A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1.
[21155626] Altern Med Rev 15(3): 245-63 (2010)
2010  
28
2010  
29
"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging.
[19897060] Biochim Biophys Acta 1804(8): 1584-90 (2010)
2010  
30
Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.
[19818879] Biochim Biophys Acta 1804(8): 1567-75 (2010)
2010  
31
Structural basis for sirtuin function: what we know and what we don't.
[19766737] Biochim Biophys Acta 1804(8): 1604-16 (2010)
2009  
32
From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis.
[19289152] Biochim Biophys Acta 1790(10): 997-1004 (2009)
2006  
33
A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins.
[17172829] Cell Cycle 5(22): 2588-91 (2006)
2010  
34
At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins.
[20458180] Cell Cycle 9(10): 1907-12 (2010)
2008  
35
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues.
[19029811] Cell Cycle 7(23): 3669-79 (2008)
2010  
36
Sirtuins and their relevance to the kidney.
[20595677] J Am Soc Nephrol 21(10): 1620-7 (2010)
2010  
37
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.
[20007326] Endocr Rev 31(2): 194-223 (2010)
2008  
38
Transcriptional targets of sirtuins in the coordination of mammalian physiology.
[18468877] Curr Opin Cell Biol 20(3): 303-9 (2008)
2011  
39
Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis.
[22016654] Int J Mol Sci 12(9): 6226-39 (2011)
2008  
40
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
[18292778] Nat Rev Mol Cell Biol 9(3): 206-18 (2008)
2009  
41
Function of sirtuins in biological tissues.
[19301279] Anat Rec (Hoboken) 292(4): 536-43 (2009)
2010  
42
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.
[20085812] Pharmacol Res 62(1): 42-7 (2010)
2010  
43
Pharmacological manipulations of CNS sirtuins: potential effects on metabolic homeostasis.
[20138996] Pharmacol Res 62(1): 48-54 (2010)
2010  
44
Mammalian sirtuins: biological insights and disease relevance.
[20078221] Annu Rev Pathol 5(-): 253-95 (2010)
2010  
45
Dietary interventions to extend life span and health span based on calorie restriction.
[20371545] J Gerontol A Biol Sci Med Sci 65(7): 695-703 (2010)
2010  
46
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.
[20025641] J Pineal Res 48(1): 9-19 (2010)
2011  
47
The dual role of sirtuins in cancer.
[21941620] Genes Cancer 2(6): 648-62 (2011)
2009  
48
Histone deacetylase inhibitors: Potential in cancer therapy.
[19459166] J Cell Biochem 107(4): 600-8 (2009)
2010  
49
Resveratrol, sirtuins, and the promise of a DR mimetic.
[20219519] Mech Ageing Dev 131(4): 261-9 (2010)
2010  
50
The molecular genetics of sirtuins: association with human longevity and age-related diseases.
[21537393] Int J Mol Epidemiol Genet 1(3): 214-25 (2010)
2010  
51
Effects of calorie restriction on life span of microorganisms.
[20721547] Appl Microbiol Biotechnol 88(4): 817-28 (2010)
2010  
52
A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 2.
[21194247] Altern Med Rev 15(4): 313-28 (2010)
2010  
53
The sirtuins in the pathogenesis of cancer.
[22704201] Clin Epigenetics 1(3-4): 71-83 (2010)
2010  
54
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.
[20863707] Trends Biochem Sci 35(12): 669-75 (2010)

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