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lüll Resveratrol-activated SIRT1 in liver and pancreatic beta-cells: a Janus head looking to the same direction of metabolic homeostasis Vetterli L; Maechler PAging (Albany NY) 2011[Apr]; 3 (4): 444-9Sirtuins are energy sensors which mediate effects of calorie restriction-induced lifespan extension. The mammalian sirtuin homolog SIRT1 is a protein deacetylase playing a central role in metabolic homeostasis. SIRT1 is one of the targets of resveratrol, a polyphenol that has been shown to increase lifespan and to protect animal models against high-calorie diet induced obesity and insulin resistance. The beneficial effects of resveratrol mediated by SIRT1 activation can be contributed by different organs. Among them, the liver and pancreatic beta-cells have been shown to be responsive to resveratrol in a SIRT1-dependent manner. Downstream of SIRT1, transcription factors being activated are tissue-specific, in turn inducing expression of metabolic genes in an apparent paradoxical way. In this review, we discuss specificities of SIRT1 effects in the liver versus pancreatic beta-cells, ultimately converging towards metabolic homeostasis at the organism level.|Adenylate Kinase/metabolism[MESH]|Animals[MESH]|Antioxidants/pharmacology[MESH]|Energy Metabolism/*drug effects[MESH]|Enzyme Activation/drug effects[MESH]|Glucose/metabolism[MESH]|Homeostasis/*drug effects[MESH]|Insulin-Secreting Cells/*drug effects/*metabolism[MESH]|Insulin/metabolism[MESH]|Liver/cytology/*drug effects/*metabolism[MESH]|Resveratrol[MESH]|Sirtuin 1/*metabolism[MESH]|Stilbenes/*pharmacology[MESH]|Transcription Factors/metabolism[MESH] |