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lüll A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis Imai SPharmacol Res 2010[Jul]; 62 (1): 42-7Aging science has recently drawn much attention, and discussions on the possibility of anti-aging medicine have multiplied. One potential target for the development of anti-aging drugs is the SIR2 (silent information regulator 2) family of NAD-dependent deacetylases/ADP-ribosyltransferases, called "sirtuins." Sirtuins regulate many fundamental biological processes in response to a variety of environmental and nutritional stimuli. In mammals, the mammalian SIR2 ortholog SIRT1 has been most studied, and small molecule SIRT1 activators (STACs), including a plant-derived polyphenolic compound resveratrol, have been developed. On the other hand, sirtuin activity is regulated by NAD biosynthetic pathways, and nicotinamide phosphoribosyltransferase (NAMPT) plays a critical role in the regulation of mammalian sirtuin activity. Recent studies have provided a proof of concept for the idea that nicotinamide mononucleotide (NMN), the NAMPT reaction product, can be used as a nutriceutical to activate SIRT1 activity. Based on these recent findings, the possibility of sirtuin-targeted nutriceutical development will be discussed.|Aging/*drug effects/metabolism[MESH]|Animals[MESH]|Drug Design[MESH]|Enzyme Activation[MESH]|Flavonoids/*pharmacology[MESH]|Humans[MESH]|NAD/*biosynthesis[MESH]|Nicotinamide Mononucleotide/*pharmacology[MESH]|Nicotinamide Phosphoribosyltransferase/physiology[MESH]|Phenols/*pharmacology[MESH]|Polyphenols[MESH]|Sirtuins/*metabolism[MESH]|Small Molecule Libraries/*pharmacology[MESH] |