PI3K

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PI3K

LE WE PMID CA

PI3K

2208

PI3K

ARF

Bax

Calcium (Endoplasmic reticulum)

Calcium (Intracellular)

Cell migration

CNS (Neoplasia Glioblastoma)

Endothelial dysfunction

Epithelio mesenchymal transition

GDC0941

Insulin (resistance)

LY294002

Mitochondria (Permeability transition)

MTOR

mTORC1

mTORC2

p110alpha

PAR4

PDK1

Phosphatidylinositol phosphate

PI103

PI3K

PIKE

PIKK

Protein kinase B Akt

PTEN MMAC1 TEP1

Rac

RHEB

TGF beta

Thapsigargin

TSC1 Hamartin

TSC2 Tuberin

Wortmannin

2007 1	The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. [19384426] Curr Genomics 8(5): 271-306 (2007)
2009 2	Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy. [19139107] Mol Cancer Ther 8(1): 1-9 (2009)
2008 3	Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy. [18616528] Cancer Sci 99(9): 1734-40 (2008)
2006 4	The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target. [16540633] Cancer Res 66(6): 2889-92 (2006)
2003 5	The phosphoinositide (PI) 3-kinase family. [12829733] J Cell Sci 116(Pt 15): 3037-40 (2003)
2001 6	Phosphoinositide 3-kinase signalling pathways. [11282020] J Cell Sci 114(Pt 8): 1439-45 (2001)
1992 7	Phosphatidylinositol 3-kinase: a novel effector. [1332743] Cell Growth Differ 3(10): 747-52 (1992)
2001 8	Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment. [11566615] Endocr Relat Cancer 8(3): 237-48 (2001)
1999 9	Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways. [10092582] J Biol Chem 274(14): 9129-32 (1999)
1999 10	The role of phosphoinositide 3-kinase lipid products in cell function. [10085060] J Biol Chem 274(13): 8347-50 (1999)
2007 11	Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. [17641274] J Endocrinol 194(2): 243-56 (2007)
1998 12	PI 3-kinase. [9822588] Curr Biol 8(23): R828 (1998)
2009 13	PI3K/PTEN signaling in angiogenesis and tumorigenesis. [19595306] Adv Cancer Res 102(-): 19-65 (2009)
2004 14	Molecular targeting: PI3 kinase pathway. [15477314] Ann Oncol 15 Suppl 4(-): iv233-9 (2004)
2010 15	Status of PI3K inhibition and biomarker development in cancer therapeutics. [19713247] Ann Oncol 21(4): 683-91 (2010)
2010 16	Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design. [19962457] Biochim Biophys Acta 1804(3): 533-40 (2010)
2003 17	Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. [12851486] Cell Cycle 2(4): 339-45 (2003)
2007 18	New functions for PI3K in the control of cell division. [17598985] Cell Cycle 6(14): 1696-8 (2007)
2009 19	Phosphoinositide 3-kinase signalling in the vascular system. [19038971] Cardiovasc Res 82(2): 261-71 (2009)
2008 20	The regulation of cell motility and chemotaxis by phospholipid signaling. [18287584] J Cell Sci 121(Pt 5): 551-9 (2008)
2010 21	Multiple functions of phosphoinositide-3 kinase enhancer (PIKE). [20419274] ScientificWorldJournal 10(-): 613-23 (2010)
2008 22	An integrated view of insulin resistance and endothelial dysfunction. [18775359] Endocrinol Metab Clin North Am 37(3): 685-711, ix-x (2008)
2010 23	Targeting the PI3K signaling pathway in cancer. [20006486] Curr Opin Genet Dev 20(1): 87-90 (2010)
2009 24	PI 3-kinase and cancer: changing accents. [19185485] Curr Opin Genet Dev 19(1): 12-7 (2009)
2010 25	Drugging the PI3 kinome: from chemical tools to drugs in the clinic. [20179189] Cancer Res 70(6): 2146-57 (2010)
2010 26	Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs. [21317449] Oncotarget 1(7): 530-43 (2010)
2007 27	Dual effect of thapsigargin on cell death in porcine aortic smooth muscle cells. [17218371] Am J Physiol Cell Physiol 292(1): C383-95 (2007)
2010 28	The PI3K pathway as drug target in human cancer. [20085938] J Clin Oncol 28(6): 1075-83 (2010)
2009 29	PTEN and the PI3-kinase pathway in cancer. [18767981] Annu Rev Pathol 4(-): 127-50 (2009)
2011 30	Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition. [21041997] Cells Tissues Organs 193(1-2): 8-22 (2011)
2011 31	PI3Kinase signaling in glioblastoma. [21063898] J Neurooncol 103(3): 417-27 (2011)
2011 32	RAS Interaction with PI3K: More Than Just Another Effector Pathway. [21779497] Genes Cancer 2(3): 261-74 (2011)
2010 33	Inhibitors of phosphatidylinositol-3-kinase in cancer therapy. [20176047] Mol Aspects Med 31(2): 135-44 (2010)
2009 34	Emerging common themes in regulation of PIKKs and PI3Ks. [19779456] EMBO J 28(20): 3067-73 (2009)
2010 35	Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer. [21537480] World J Biol Chem 1(8): 239-47 (2010)
2009 36	A complex interplay between Akt, TSC2 and the two mTOR complexes. [19143635] Biochem Soc Trans 37(Pt 1): 217-22 (2009)
2010 37	Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance. [20535652] Curr Top Microbiol Immunol 347(-): 279-96 (2010)
2010 38	Structural effects of oncogenic PI3Kα mutations. [20593314] Curr Top Microbiol Immunol 347(-): 43-53 (2010)
2002 39	Phosphoinositide 3-kinases in immunity: lessons from knockout mice. [11926985] J Biochem 131(4): 495-501 (2002)

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