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lüll Targeting the PI3K signaling pathway in cancer Wong KK; Engelman JA; Cantley LCCurr Opin Genet Dev 2010[Feb]; 20 (1): 87-90The phosphoinositide 3-kinase (PI3K) pathway is activated in a variety of different human cancers, and inhibitors of this pathway are under active development as anti-cancer therapeutics. In this review, we discuss the data supporting the use of PI3K pathway inhibitors in genetically and clinically defined cancers. This review focuses on their efficacy as single agents and in combination with other targeted therapies, specifically those targeting the MEK-ERK signaling pathway.|*Phosphoinositide-3 Kinase Inhibitors[MESH]|Antineoplastic Agents/*therapeutic use[MESH]|Antineoplastic Combined Chemotherapy Protocols/therapeutic use[MESH]|Humans[MESH]|MAP Kinase Kinase Kinases[MESH]|Neoplasms/*drug therapy[MESH]|Phosphatidylinositol 3-Kinases/genetics[MESH]|Receptor, ErbB-2/antagonists & inhibitors[MESH]|Signal Transduction/drug effects[MESH] |