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lüll Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Stein RCEndocr Relat Cancer 2001[Sep]; 8 (3): 237-48The phosphoinositide 3-kinases (PI3-kinases) are a family of lipid kinases that have a key role in the regulation of many cellular processes including proliferation, survival, carbohydrate metabolism, and motility. There is now strong evidence that some members of the PI3-kinase family have an important role in cancer. Emerging evidence for functional specialisation of PI3-kinase isoforms suggests that isoform selective inhibitors, in contrast to the existing non-selective inhibitors wortmannin and LY294002, may prove to be useful anticancer drugs.|*Phosphoinositide-3 Kinase Inhibitors[MESH]|Animals[MESH]|Antineoplastic Agents/*therapeutic use[MESH]|Enzyme Inhibitors/*therapeutic use[MESH]|Humans[MESH]|Lipid Metabolism[MESH]|Neoplasms/*drug therapy/enzymology[MESH]|Phosphatidylinositol 3-Kinases/metabolism[MESH] |