Statin

Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled trials.
[18299289] BMJ 336(7645): 645-51 (2008)

Use of statins in patients with chronic hepatitis C.
[20818300] South Med J 103(10): 1018-22; quiz 1023 (2010)

Primary evaluation and management of statin therapy complications.
[16553099] South Med J 99(3): 250-6 (2006)

Interaction between statins and clopidogrel: is there anything clinically relevant?
[18676683] QJM 101(12): 915-25 (2008)

Statins in patients with chronic kidney disease: evidence from systematic reviews and randomized clinical trials.
[16719546] PLoS Med 3(5): e123 (2006)

Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials.
[17130382] Arch Intern Med 166(21): 2307-13 (2006)

Therapy with hydroxymethylglutaryl coenzyme a reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: evidence from the Cardiovascular Health Study.
[12076239] Arch Intern Med 162(12): 1395-400 (2002)

Clinical outcomes in statin treatment trials: a meta-analysis.
[10448784] Arch Intern Med 159(15): 1793-802 (1999)

Perioperative statins: more than lipid-lowering?
[18788226] Cleve Clin J Med 75(9): 654-62 (2008)

Safety of statins: effects on muscle and the liver.
[16315438] Cleve Clin J Med 72(11): 990-3, 996-1001 (2005)

Statins: the case for higher, individualized starting doses.
[16193828] Cleve Clin J Med 72(9): 811-6 (2005)

Statin myopathies: pathophysiologic and clinical perspectives.
[11603510] Clin Invest Med 24(5): 258-72 (2001)

The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease.
[15179443] CNS Drug Rev 10(2): 127-46 (2004)

Statins and cognition: what can we learn from existing randomized trials?
[16273014] CNS Spectr 10(11): 867-74 (2005)

American, British and European recommendations for statins in the primary prevention of cardiovascular disease applied to British men studied prospectively.
[16717068] Heart 92(9): 1213-8 (2006)

Reducing morbidity and mortality in high risk patients with statins.
[19554090] Vasc Health Risk Manag 5(2): 495-507 (2009)

Clinical efficacy and safety of statins in managing cardiovascular risk.
[18561510] Vasc Health Risk Manag 4(2): 341-53 (2008)

Ongoing clinical trials of the pleiotropic effects of statins.
[17319096] Vasc Health Risk Manag 1(1): 29-40 (2005)

Statins in the treatment of chronic heart failure: biological and clinical considerations.
[16730683] Cardiovasc Res 71(3): 443-54 (2006)

Cardiac effects of statins--advancements and open questions.
[15914106] Cardiovasc Res 66(3): 427-9 (2005)

Statins--is there no end to their usefulness?
[15639466] Cardiovasc Res 65(2): 296-8 (2005)

Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease.
[11164838] Cardiovasc Res 49(2): 281-7 (2001)

A systematic review and economic evaluation of statins for the prevention of coronary events.
[17408535] Health Technol Assess 11(14): 1-160, iii-iv (2007)

The statins as anticancer agents.
[12538446] Clin Cancer Res 9(1): 10-9 (2003)

Why should statins prevent venous thromboembolism? A systematic literature search and a call for action.
[16961599] J Thromb Haemost 4(9): 1925-7 (2006)

Narrative review: statin-related myopathy.
[19528564] Ann Intern Med 150(12): 858-68 (2009)

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
[11701455] Arterioscler Thromb Vasc Biol 21(11): 1712-9 (2001)

Inhibition of RhoA or Rac1? Mechanism of cholesterol-independent beneficial effects of statins.
[19164861] Circ J 73(2): 231-2 (2009)

Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.
[17525375] Circ Res 100(10): 1394-5 (2007)

Risks associated with statin therapy: a systematic overview of randomized clinical trials.
[17159064] Circulation 114(25): 2788-97 (2006)

HMG-CoA reductase inhibitors and renal function.
[17942762] Clin J Am Soc Nephrol 2(6): 1100-3 (2007)

Statin-induced diabetes: will it change clinical practice?
[19794006] Diabetes Care 32(10): 1941-3 (2009)

Statin therapy and risk of developing type 2 diabetes: a meta-analysis.
[19794004] Diabetes Care 32(10): 1924-9 (2009)

Statins for improving renal outcomes: a meta-analysis.
[16762986] J Am Soc Nephrol 17(7): 2006-16 (2006)

REVIEW: Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia.
[16291700] J Clin Endocrinol Metab 91(2): 383-92 (2006)

Clinical review 145: Pleiotropic effects of statins: lipid reduction and beyond.
[11932263] J Clin Endocrinol Metab 87(4): 1451-8 (2002)

The discovery and development of HMG-CoA reductase inhibitors.
[1464741] J Lipid Res 33(11): 1569-82 (1992)

Statins and cancer risk: a meta-analysis.
[16391219] JAMA 295(1): 74-80 (2006)

The use of statins in pediatrics: knowledge base, limitations, and future directions.
[17272627] Pediatrics 119(2): 370-80 (2007)

ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins.
[12215610] Stroke 33(9): 2337-41 (2002)

Pleiotropic effects of statins: benefit beyond cholesterol reduction? A meta-regression analysis.
[16286171] J Am Coll Cardiol 46(10): 1855-62 (2005)

The efficacy and safety of intensive statin therapy: a meta-analysis of randomized trials.
[18299547] CMAJ 178(5): 576-84 (2008)

Does pravastatin promote cancer in elderly patients? A meta-analysis.
[17325332] CMAJ 176(5): 649-54 (2007)

Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.
[19159124] Am J Cardiovasc Drugs 8(6): 373-418 (2008)

Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials.
[21411487] BMJ 342(-): d1250 (2011)

Statin myopathy: a common dilemma not reflected in clinical trials.
[21632911] Cleve Clin J Med 78(6): 393-403 (2011)

Statins and noncardiac surgery: current evidence and practical considerations.
[19880840] Cleve Clin J Med 76 Suppl 4(-): S79-83 (2009)

Effects of statins on renal function.
[17976359] Mayo Clin Proc 82(11): 1381-90 (2007)

Do statins reduce blood pressure?: a meta-analysis of randomized, controlled trials.
[17309949] Hypertension 49(4): 792-8 (2007)

Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis.
[12039998] J Am Soc Nephrol 13(6): 1673-81 (2002)

Are 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors renoprotective?
[15938026] J Am Soc Nephrol 16 Suppl 1(-): S11-7 (2005)

Statin therapy: beyond cholesterol lowering and antiinflammatory effects.
[12081982] Circulation 105(25): 2937-8 (2002)

Impact of angiotensin-converting enzyme inhibitors and statins on survival in idiopathic pulmonary fibrosis.
[15302729] Chest 126(2): 438-46 (2004)

Statins in COPD: a systematic review.
[19376844] Chest 136(3): 734-43 (2009)

Antimicrobial and immunomodulatory attributes of statins: relevance in solid-organ transplant recipients.
[19193110] Clin Infect Dis 48(6): 745-55 (2009)

Mevalonate pathway is a novel target for hypertension.
[21532185] Circ J 75(6): 1318-9 (2011)

Sympathoinhibitory effects of atorvastatin in hypertension.
[21088328] Circ J 74(12): 2552-3 (2010)

Pleiotropic effects of statins. - Basic research and clinical perspectives -.
[20424337] Circ J 74(5): 818-26 (2010)

Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins.
[21071715] Circ Res 107(10): 1170-84 (2010)

Endothelium-dependent effects of statins.
[12615672] Arterioscler Thromb Vasc Biol 23(5): 729-36 (2003)

Rapid effects of statins: from prophylaxis to therapy for ischemic stroke.
[12588752] Arterioscler Thromb Vasc Biol 23(2): 156-7 (2003)

A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia.
[17569881] Arterioscler Thromb Vasc Biol 27(8): 1803-10 (2007)

Do statins have an antiarrhythmic activity?
[17383620] Cardiovasc Res 75(1): 10-20 (2007)

Effect of statin treatment on vasospasm, delayed cerebral ischemia, and functional outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis update.
[19875741] Stroke 41(1): e47-52 (2010)

'Yes' or 'no' to routine statins after subarachnoid hemorrhage to prevent delayed cerebral ischaemia, vasospasm, and death? A cautionary tale of 2 meta-analyses.
[19959535] Stroke 41(1): e1-2 (2010)

Statin therapy for stroke prevention.
[18258828] Stroke 39(3): 1042-8 (2008)

Effect of statins on intracerebral hemorrhage outcome and recurrence.
[18436876] Stroke 39(7): 2151-4 (2008)

Statins for primary and secondary prevention of coronary heart disease. A scientific review.
[15058150] Rev Port Cardiol 23(1): 95-122 (2004)

The role of statins in aortic stenosis. Myth or reality?
[17427836] Rev Port Cardiol 26(1): 51-62 (2007)

Effect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER Database.
[19965573] J Lipid Res 51(6): 1546-53 (2010)

Pharmacogenomics of cardiovascular pharmacology: molecular network analysis in pleiotropic effects of statin -- an experimental elucidation of the pharmacologic action from protein-protein interaction analysis.
[18490854] J Pharmacol Sci 107(1): 15-9 (2008)

ASH evidence-based guidelines: statins in the prevention of venous thromboembolism.
[20008210] Hematology Am Soc Hematol Educ Program -(-): 273-4 (2009)

Isoprenoids as mediators of the biological effects of statins.
[12163444] J Clin Invest 110(3): 285-8 (2002)

Statin drugs and dietary isoprenoids downregulate protein prenylation in signal transduction and are antithrombotic and prothrombolytic agents.
[11841343] Biochemistry (Mosc) 67(1): 85-91 (2002)

HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma.
[15856040] Br J Cancer 92(9): 1593-8 (2005)

Targeting targets for LDL-lowering therapy: lessons from the Collaborative Atorvastatin Diabetes Study (CARDS).
[19147725] Clin Chem 55(3): 391-3 (2009)

Statins: rhabdomyolysis and myopathy.
[11800260] CMAJ 166(1): 85-6, 90-1 (2002)

Novel mechanistic and clinical implications concerning the safety of statin discontinuation.
[22001974] Pharmacol Rep 63(4): 867-79 (2011)

Statin-induced myopathies.
[22001973] Pharmacol Rep 63(4): 859-66 (2011)

Drug-induced myopathies. An overview of the possible mechanisms.
[15849374] Pharmacol Rep 57(1): 23-34 (2005)

Statins: a new insight into their mechanisms of action and consequent pleiotropic effects.
[18048949] Pharmacol Rep 59(5): 483-99 (2007)

Do statins slow the process of calcification of aortic tissue valves?
[20570976] Interact Cardiovasc Thorac Surg 11(3): 297-301 (2010)

Benefits of statin therapy and compliance in high risk cardiovascular patients.
[20957130] Vasc Health Risk Manag 6(-): 843-53 (2010)

The acute (cerebro)vascular effects of statins.
[19608834] Anesth Analg 109(2): 572-84 (2009)

Statins for all: the new premed?
[19502286] Br J Anaesth 103(1): 99-107 (2009)

Beneficial effects of statins on the kidney.
[15252929] J Clin Pathol 57(7): 673-4 (2004)

A historical perspective on the discovery of statins.
[20467214] Proc Jpn Acad Ser B Phys Biol Sci 86(5): 484-93 (2010)

Clinical utility of rosuvastatin and other statins for cardiovascular risk reduction among the elderly.
[21472089] Clin Interv Aging 6(-): 27-35 (2011)

Regulation of different inflammatory diseases by impacting the mevalonate pathway.
[19191903] Immunology 127(1): 18-25 (2009)

Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin.
[21561413] Curr Drug Targets 12(8): 1223-31 (2011)

Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo.
[20299472] Diabetes 59(6): 1386-96 (2010)

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases.
[20837848] Arch Neurol 67(9): 1062-7 (2010)

Summary of the role of statins in the treatment of dyslipidemia.
[12884937] J Am Osteopath Assoc 103(7 Suppl 3): S1-3 (2003)

Weight of the evidence in statin clinical trials: comparing the results.
[12884938] J Am Osteopath Assoc 103(7 Suppl 3): S4-11 (2003)

Lipid and nonlipid benefits of statins.
[12884939] J Am Osteopath Assoc 103(7 Suppl 3): S12-7 (2003)

Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy.
[19199975] Curr Pharm Des 15(5): 467-78 (2009)

Molecular mechanisms of HDL-cholesterol elevation by statins and its effects on HDL functions.
[20513953] J Atheroscler Thromb 17(5): 436-51 (2010)

Recent trials of lipid lowering.
[17577297] Int J Clin Pract 61(7): 1145-59 (2007)

Spectrum of pleiotropic effects of statins in heart failure.
[18433695] Heart Fail Clin 4(2): 153-61 (2008)

Statin therapy in metabolic syndrome and hypertension post-JUPITER: what is the value of CRP?
[21046291] Curr Atheroscler Rep 13(1): 31-42 (2011)

The anti-ischemic and anti-anginal properties of statins.
[21107759] Curr Atheroscler Rep 13(1): 43-50 (2011)

Statins reduce stroke risk by one-fifth.
[19575094] Cardiovasc J Afr 20(3): 208-9 (2009)

Statins for secondary prevention of cardiovascular disease: the right dose.
[21228612] Pharmacology 87(1-2): 63-9 (2011)

Effects of statins on high-density lipoproteins: a potential contribution to cardiovascular benefit.
[18553127] Cardiovasc Drugs Ther 22(4): 321-38 (2008)

Are statins effective for simultaneously treating dyslipidemias and hypertension?
[17662294] Atherosclerosis 196(1): 1-8 (2008)

Effect of early versus late in-hospital initiation of statin therapy on the clinical outcomes of patients with acute coronary syndrome.
[18160760] Int Heart J 48(6): 677-88 (2007)

A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
[14572163] Ann Med 35(6): 398-403 (2003)

Effect of apolipoprotein E polymorphism on statin-induced decreases in plasma lipids and cardiovascular events.
[21557673] Drug Metabol Drug Interact 26(1): 13-20 (2011)

Statins: cardiovascular risk reduction in percutaneous coronary intervention-basic and clinical evidence of hyperacute use of statins.
[21461336] Int J Hypertens 2011(-): 904742 (2011)

Anti-angiogenic and anti-inflammatory effects of statins: relevance to anti-cancer therapy.
[16375664] Curr Cancer Drug Targets 5(8): 579-94 (2005)

Prospects of statins in Parkinson disease.
[21252380] Neuroscientist 17(3): 244-55 (2011)

Coenzyme q10 and statin-induced mitochondrial dysfunction.
[21603349] Ochsner J 10(1): 16-21 (2010)

The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
[24391721] PLoS One 8(12):e82775 (2013)

Association between statin medications and mortality, major adverse cardiovascular event, and amputation-free survival in patients with critical limb ischemia.
[24315911] J Am Coll Cardiol 63(7):682-90 (2014)

Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering.
[24111702] Antioxid Redox Signal 20(8):1198-215 (2014)

Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins.
[23924190] Antioxid Redox Signal 20(8):1268-85 (2014)

Effect of two intensive statin regimens on progression of coronary disease.
[C3861278] Indian Heart J 64(1):116-7 (2012)

Statin use and risk of delirium in the critically ill.
[24417431] Am J Respir Crit Care Med 189(6):666-73 (2014)

HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size.
[15905463] Circ Res 96(11):1185-92 (2005)

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