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lüll Clinical efficacy and safety of statins in managing cardiovascular risk Kapur NK; Musunuru KVasc Health Risk Manag 2008[]; 4 (2): 341-53Since their introduction in the 1980s, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have emerged as the one of the best-selling medication classes to date, with numerous trials demonstrating powerful efficacy in preventing cardiovascular outcomes. As our understanding of low-density lipoprotein cholesterol (LDL-C) and atherosclerosis continues to grow, the concept of 'lower is better' has corresponded with a more is better' approach to statin-based therapy. This review provides a detailed understanding of the clinical efficacy and safety of statins with a particular emphasis on the third generation drug, rosuvastatin.|Atherosclerosis/drug therapy/etiology[MESH]|Cardiovascular Diseases/blood/etiology/*prevention & control[MESH]|Chemical and Drug Induced Liver Injury[MESH]|Cholesterol, LDL/blood[MESH]|Fluorobenzenes/adverse effects/*therapeutic use[MESH]|Humans[MESH]|Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/*therapeutic use[MESH]|Hypercholesterolemia/blood/complications/*drug therapy[MESH]|Kidney Diseases/chemically induced[MESH]|Muscular Diseases/chemically induced[MESH]|Pyrimidines/adverse effects/*therapeutic use[MESH]|Risk Assessment[MESH]|Risk Factors[MESH]|Rosuvastatin Calcium[MESH]|Sulfonamides/adverse effects/*therapeutic use[MESH]|Treatment Outcome[MESH] |