LE WE PMID CA
Protein kinase B Akt2307Protein Kinase B Akt

4 phenylbutyrate

AMP activated protein kinase

Antineoplastic agents (Novel target ideas)

ARF

Autophagy

Caveolin and caveoles

CCI779

Cell cylce (BASKET)

Cell migration

Cell Secretion (Exosomes)

Cell stress (Genotoxic)

Cell stress (Redox)

Chk1

Chmp4C

Diabetes mellitus (BASKET)

Diabetes mellitus (Beta cell decay)

DRAM

Endosom

ERS UFR (Apoptosis)

ERS UFR (Diseases)

ERS UFR (Induced Mediators)

ERS UFR (Pharmacology)

FoxO3A

GADD153 CHOP

GSK3

Hydrogensulfide

IGF1

IGFBP3

Lipotoxicity

Mammary gland (Neoplasia)

Mitochondria (BASKET)

MTOR

mTORC1

mTORC2

Nelfinavir

Neoplasia (Tumor biology and immunology)

Oleic acid

Osteoarthritis

P38MAPK

P53

PAR4

Pentose shunt

Perifosine ttPKB

PHLPP1

PHLPP2

Phosphatidylinositol phosphate

PI3K

PIP5K3 PIKfyve

Placenta (Pathology)

Protein kinase (BASKET)

Protein kinase B Akt

Protein kinase C

PTEN MMAC1 TEP1

PUMA

PX866 ttPKB

Rac

RAD001 ttMTOR

Ritonavir

Saquinavir

SB212090 ttp38MAPK

Sestrin1

Sestrin2

SGK1

Statin

TRB3

TRPV6

TSAP6

TSC2 Tuberin

Ubc3 Cdc34

UbcH10

UbcH7

Ubiquitin

Warburg effect

Wortmannin

2010  
1
Physiological regulation of Akt activity and stability.
[20182580] Am J Transl Res 2(1): 19-42 (2010)
2009  
2
3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase.
[19568789] J Chem Biol 2(1): 11-25 (2009)
2008  
3
Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules.
[19568798] J Chem Biol 1(1-4): 49-62 (2008)
2006  
4
The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target.
[16540633] Cancer Res 66(6): 2889-92 (2006)
2005  
5
Protein kinase B/Akt at a glance.
[16339964] J Cell Sci 118(Pt 24): 5675-8 (2005)
2001  
6
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
[11686294] J Cell Sci 114(Pt 16): 2903-10 (2001)
2007  
7
AKT/PKB signaling: navigating downstream.
[17604717] Cell 129(7): 1261-74 (2007)
2006  
8
Akt/PKB signaling in cancer: a function in cell motility and invasion.
[16582622] Cell Cycle 5(6): 603-5 (2006)
2005  
9
Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.
[16179727] Exp Biol Med (Maywood) 230(9): 593-605 (2005)
2002  
10
Akt: versatile mediator of cell survival and beyond.
[16248975] J Biochem Mol Biol 35(1): 106-15 (2002)
2005  
11
The survival kinases Akt and Pim as potential pharmacological targets.
[16200194] J Clin Invest 115(10): 2618-24 (2005)
2002  
12
PKB binding proteins. Getting in on the Akt.
[12419241] Cell 111(3): 293-303 (2002)
2003  
13
Unravelling the activation mechanisms of protein kinase B/Akt.
[12829245] FEBS Lett 546(1): 108-12 (2003)
2008  
14
Contribution of natural inhibitors to the understanding of the PI3K/PDK1/PKB pathway in the insulin-mediated intracellular signaling cascade.
[19330070] Int J Mol Sci 9(11): 2217-30 (2008)
2010  
15
Regulation of Akt signaling activation by ubiquitination.
[20081374] Cell Cycle 9(3): 487-97 (2010)
2008  
16
The regulation of cell motility and chemotaxis by phospholipid signaling.
[18287584] J Cell Sci 121(Pt 5): 551-9 (2008)
2009  
17
Lipid activation of protein kinases.
[19033211] J Lipid Res 50 Suppl(-): S266-71 (2009)
2008  
18
Pharmacogenomics of cardiovascular pharmacology: molecular network analysis in pleiotropic effects of statin -- an experimental elucidation of the pharmacologic action from protein-protein interaction analysis.
[18490854] J Pharmacol Sci 107(1): 15-9 (2008)
2010  
19
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.
[20182617] Cold Spring Harb Perspect Biol 2(2): a001057 (2010)
2005  
20
Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications.
[15717836] Physiol Res 54(1): 1-16 (2005)
2010  
21
Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs.
[21317449] Oncotarget 1(7): 530-43 (2010)
2010  
22
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.
[20399660] Trends Cell Biol 20(7): 427-34 (2010)
2009  
23
Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.
[19130886] Semin Cancer Biol 19(1): 25-31 (2009)
2009  
24
Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7.
[19664228] Cell Div 4(-): 17 (2009)
2009  
25
Current perspectives on Akt Akt-ivation and Akt-ions.
[19596822] Exp Biol Med (Maywood) 234(11): 1264-70 (2009)
2008  
26
Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.
[18583310] Am J Pathol 173(2): 451-62 (2008)
2009  
27
Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis.
[19180501] Arthritis Rheum 60(2): 492-500 (2009)
2008  
28
Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy.
[18000394] Autophagy 4(1): 107-9 (2008)
2011  
29
Hydrogen sulphide protects mouse pancreatic beta-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress.
[21091646] Br J Pharmacol 162(5): 1171-8 (2011)
2005  
30
Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression.
[16294033] Cancer Biol Ther 4(10): 1063-7 (2005)
2010  
31
TRB3 function in cardiac endoplasmic reticulum stress.
[20360254] Circ Res 106(9): 1516-23 (2010)
2007  
32
Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.
[17785575] Clin Cancer Res 13(17): 5183-94 (2007)
2011  
33
Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle.
[21505048] Endocrinology 152(6): 2206-18 (2011)
2009  
34
The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I.
[18801901] Endocrinology 150(1): 277-85 (2009)
2008  
35
PHLiPPing the switch on Akt and protein kinase C signaling.
[18511290] Trends Endocrinol Metab 19(6): 223-30 (2008)
2010  
36
Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts.
[20398329] Breast Cancer Res 12(2): 202 (2010)
2010  
37
Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve.
[20041238] J Membr Biol 233(1-3): 35-41 (2010)
2008  
38
Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.
[18166498] Drug Resist Updat 11(1-2): 32-50 (2008)
2009  
39
Switching Akt: from survival signaling to deadly response.
[19319914] Bioessays 31(5): 492-5 (2009)
2009  
40
Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue.
[19377835] J Bioenerg Biomembr 41(2): 169-80 (2009)

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  • Protein Kinase B Akt

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