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Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules Gunn RM; Hailes HCJ Chem Biol 2008[Nov]; 1 (1-4): 49-62This review describes the progress that has been made in understanding the PI3-K-PKB-mTOR signalling pathway by using small molecules as pharmacological probes. It briefly covers the structural characteristics, regulation of and downstream effects of several key regulators of PI3-K-PKB-mTOR signalling, then highlights the use of small molecules (by structural type) to selectively modulate specific components of the pathway.ä |
