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PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?Lawlor MA; Alessi DRJ Cell Sci 2001[Aug]; 114 (Pt 16): 2903-10The serine/threonine protein kinase PKB (also known as Akt) is thought to be a key mediator of signal transduction processes. The identification of PKB substrates and the role PKB phosphorylation plays in regulating these molecules have been a major focus of research in recent years. A recently developed motif-profile scoring algorithm that can be used to scan the genome for potential PKB substrates is therefore a useful tool, although additional considerations, such as the evolutionary conservation of the phosphorylation site, must also be taken into account. Recent evidence indicates that PKB plays a key role in cancer progression by stimulating cell proliferation and inhibiting apoptosis and is also probably a key mediator of insulin signalling. These findings indicate that PKB is likely to be a hot drug target for the treatment of cancer, diabetes and stroke. There are, however, a number of pitfalls of methodologies currently employed to study PKB function, and therefore caution should be used in interpretation of such experiments.|*Protein Serine-Threonine Kinases[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Apoptosis[MESH]|Cell Division[MESH]|Cell Survival[MESH]|Diabetes Mellitus/metabolism/pathology/therapy[MESH]|Humans[MESH]|Insulin/*metabolism[MESH]|Neoplasms/metabolism/pathology/therapy[MESH]|Phosphorylation[MESH]|Proto-Oncogene Proteins c-akt[MESH]|Proto-Oncogene Proteins/antagonists & inhibitors/*metabolism[MESH] |
