LE WE PMID CA
JNK 1392JNK

1 1 Bis 3 indolyl 1 p substituted phenyl methanes C DIM

Agouti related peptide AgRP

AGRP neuron

Angiogenesis

APC (Adenomatous polyposis coli)

Apoptosis

Ask1

ATG5

ATG6 Beclin1

Autophagy

Bax

bFGF

Bid

Cardiovascular risk

Caspase9

CathepsinB

CD36 FAT fatty acid translocase

CD95 FAS Apo1

Cdc2

Cell Death (Lipoapoptosis)

Cell stress (ER stress)

Ceramide synthase6

Ceramide

Cisplatin

CNS (Neoplasia Glioblastoma)

CNS (Neoplasia Glioma)

Diabetes mellitus (Beta cell decay)

Diabetes mellitus (Involvement heart and vessels)

DP5

EIF2AK3 PERK

ERS UFR (Apoptosis)

ERS UFR (Induced Mediators)

ERS UFR (Pharmacology)

ERS UFR (Toxikologie)

Etoposide

Fatty acids (Free)

Fatty acids (saturated)

Fenretinide

Foam cell

GADD153 CHOP

GADD45A

GADD45gamma

GSK3

IETD ttCaspase9

iNOS

Interleukin24 MDA7

JNK

JunB

Kidney (Neoplasia RCC)

LEHD ttCaspase9

Lipotoxicity

Lysophosphatidylcholine

Macrophages

Nephroprotective renoprotective agents

Non steroidal anti inflammatory drugs

NR4A1 Nur77

Nutrition (Neuroendocrinology)

P38MAPK

Palmitate

PLAB placental bone morphogenetic proteinPLAB

PTEN MMAC1 TEP1

PUMA

Radiation therapy

Receptor (Interleukin20)

Receptor (PPAR gamma)

Salubrinal

SAPK

SP600125 ttJNK1 ttJNK2 ttJNK3

Sphingomyelinase

STAT3

Thioredoxin

Txnip

VEGF

Vitamin D

Wnt beta Catenin TCF

zVAD ttCaspases

2007  
1
JNK pathway: diseases and therapeutic potential.
[17439715] Acta Pharmacol Sin 28(5): 601-8 (2007)
2006  
2
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases.
[17158707] Microbiol Mol Biol Rev 70(4): 1061-95 (2006)
2000  
3
Signal transduction by the JNK group of MAP kinases.
[11057897] Cell 103(2): 239-52 (2000)
2007  
4
The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.
[17306896] Biochim Biophys Acta 1773(8): 1341-8 (2007)
2004  
5
JNK2: a negative regulator of cellular proliferation.
[15611655] Cell Cycle 3(12): 1520-3 (2004)
2008  
6
PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.
[18299661] Autophagy 4(4): 513-5 (2008)
2008  
7
MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.
[18376144] Cancer Biol Ther 7(6): 917-33 (2008)
2004  
8
MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.
[15197348] Cancer Biol Ther 3(8): 739-51 (2004)
2003  
9
mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.
[14508103] Cancer Biol Ther 2(4): 347-53 (2003)
2006  
10
A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells.
[17178890] Cancer Res 66(24): 11922-31 (2006)
2009  
11
MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.
[19417161] Mol Cancer Ther 8(5): 1280-91 (2009)
2008  
12
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.
[18281515] Mol Cancer Ther 7(2): 297-313 (2008)
2010  
13
Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells.
[19910452] Mol Pharmacol 77(2): 298-310 (2010)
2005  
14
mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer.
[15851011] Mol Ther 11(5): 724-33 (2005)
2004  
15
Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation.
[15194048] Mol Ther 9(6): 818-28 (2004)
2012  
16
Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis.
[21995961] Am J Physiol Gastrointest Liver Physiol 302(1): G77-84 (2012)
2008  
17
Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway.
[18270325] Blood 111(8): 4365-74 (2008)
2009  
18
PLAB induction in fenretinide-induced apoptosis of ovarian cancer cells occurs via a ROS-dependent mechanism involving ER stress and JNK activation.
[19325135] Carcinogenesis 30(5): 824-31 (2009)
2008  
19
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase.
[18460448] Carcinogenesis 29(6): 1139-47 (2008)
2009  
20
Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.
[19629134] Cell Death Differ 16(11): 1539-50 (2009)
2007  
21
Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons.
[17218955] Cell Death Differ 14(5): 1011-9 (2007)
2009  
22
1,25(OH)2 vitamin d inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus.
[19667238] Circulation 120(8): 687-98 (2009)
2010  
23
Functional role of c-Jun-N-terminal kinase in feeding regulation.
[20022934] Endocrinology 151(2): 671-82 (2010)
2008  
24
2009  
25
The role of stress-activated protein kinase signaling in renal pathophysiology.
[18982195] Braz J Med Biol Res 42(1): 29-37 (2009)
2009  
26
The roles of ASK family proteins in stress responses and diseases.
[19389260] Cell Commun Signal 7(): 9 (2009)

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