Diabetes mellitus (Beta cell decay)

Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.
[18438526] Arq Bras Endocrinol Metabol 52(2): 156-65 (2008)

Nitric oxide and endoplasmic reticulum stress.
[16645155] Arterioscler Thromb Vasc Biol 26(7): 1439-46 (2006)

Macroautophagy in homeostasis of pancreatic beta-cell.
[19066457] Autophagy 5(2): 241-3 (2009)

A lipidomic screen of palmitate-treated MIN6 beta-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.
[21265737] Biochem J 435(1): 267-76 (2011)

Hydrogen sulphide protects mouse pancreatic beta-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress.
[21091646] Br J Pharmacol 162(5): 1171-8 (2011)

The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes.
[21944825] Cell Calcium 50(6): 481-90 (2011)

Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.
[21389784] Cell Cycle 10(7): 1043-9 (2011)

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis.
[20798690] Cell Death Differ 18(2): 328-37 (2011)

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.
[19629134] Cell Death Differ 16(11): 1539-50 (2009)

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria.
[14752510] Cell Death Differ 11(4): 390-402 (2004)

Musashi expression in beta-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes.
[22113197] Cell Death Dis 2(): e232 (2011)

Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.
[21568932] Curr Mol Med 11(5): 391-400 (2011)

Islet beta-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model.
[22442300] Diabetes 61(4): 818-27 (2012)

ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes.
[22442299] Diabetes 61(4): 780-1 (2012)

Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic beta-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.
[21885870] Diabetes 60(10): 2533-45 (2011)

Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans.
[21270237] Diabetes 60(3): 918-24 (2011)

beta-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency.
[20980462] Diabetes 60(1): 227-38 (2011)

In vivo misfolding of proinsulin below the threshold of frank diabetes.
[21677281] Diabetes 60(8): 2092-101 (2011)

A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice.
[19934005] Diabetes 59(2): 460-70 (2010)

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.
[19151199] Diabetes 58(4): 906-16 (2009)

Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes.
[18065517] Diabetes 57(3): 737-45 (2008)

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.
[18174526] Diabetes 57(4): 846-59 (2008)

Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.
[17563070] Diabetes 56(9): 2284-94 (2007)

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes.
[17475933] Diabetes 56(8): 2016-27 (2007)

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.
[16306347] Diabetes 54 Suppl 2(): S97-107 (2005)

Mechanisms of beta-cell death in type 2 diabetes.
[16306327] Diabetes 54 Suppl 2(): S108-13 (2005)

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes.
[21340625] Diabetologia 54(5): 1098-108 (2011)

Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome.
[19841237] Dis Model Mech 2(11-12): 582-92 (2009)

Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival.
[20534724] Endocrinology 151(8): 3577-88 (2010)

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation.
[15994758] Eur J Endocrinol 153(1): 167-76 (2005)

Modulation of apoptosis pathways by oxidative stress and autophagy in beta cells.
[22474427] Exp Diabetes Res 2012(): 647914 (2012)

Endoplasmic reticulum stress and insulin biosynthesis: a review.
[22474424] Exp Diabetes Res 2012(): 509437 (2012)

The role of endoplasmic reticulum stress in autoimmune-mediated beta-cell destruction in type 1 diabetes.
[22454627] Exp Diabetes Res 2012(): 238980 (2012)

Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic beta-cells.
[22257883] Exp Mol Med 44(2): 81-8 (2012)

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