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Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival Lavine JA; Raess PW; Stapleton DS; Rabaglia ME; Suhonen JI; Schueler KL; Koltes JE; Dawson JA; Yandell BS; Samuelson LC; Beinfeld MC; Davis DB; Hellerstein MK; Keller MP; Attie ADEndocrinology 2010[Aug]; 151 (8): 3577-88An absolute or functional deficit in beta-cell mass is a key factor in the pathogenesis of diabetes. We model obesity-driven beta-cell mass expansion by studying the diabetes-resistant C57BL/6-Leptin(ob/ob) mouse. We previously reported that cholecystokinin (Cck) was the most up-regulated gene in obese pancreatic islets. We now show that islet cholecystokinin (CCK) is up-regulated 500-fold by obesity and expressed in both alpha- and beta-cells. We bred a null Cck allele into the C57BL/6-Leptin(ob/ob) background and investigated beta-cell mass and metabolic parameters of Cck-deficient obese mice. Loss of CCK resulted in decreased islet size and reduced beta-cell mass through increased beta-cell death. CCK deficiency and decreased beta-cell mass exacerbated fasting hyperglycemia and reduced hyperinsulinemia. We further investigated whether CCK can directly affect beta-cell death in cell culture and isolated islets. CCK was able to directly reduce cytokine- and endoplasmic reticulum stress-induced cell death. In summary, CCK is up-regulated by islet cells during obesity and functions as a paracrine or autocrine factor to increase beta-cell survival and expand beta-cell mass to compensate for obesity-induced insulin resistance.|Animals[MESH]|Cell Count[MESH]|Cell Survival/genetics[MESH]|Cells, Cultured[MESH]|Cholecystokinin/*genetics/metabolism[MESH]|Diabetes Mellitus/etiology/genetics[MESH]|Insulin Resistance/genetics[MESH]|Insulin-Secreting Cells/metabolism/*pathology[MESH]|Islets of Langerhans/*metabolism/pathology[MESH]|Male[MESH]|Mice[MESH]|Mice, Inbred C57BL[MESH]|Mice, Obese[MESH]|Mice, Transgenic[MESH]|Obesity/complications/*genetics/metabolism/*pathology[MESH]|Organ Size/genetics[MESH]|Up-Regulation[MESH] |
