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RHEB
LE WE PMID CA
RHEB9625RHEB

Amino acid (Depletion)

Asparaginase

ATG7

Autophagy

Farnesyl transferase

Glucose (Depletion)

MTOR

mTORC1

mTORC2

Neoplasia (Carcinogenesis)

Nutrient sensing

PI3K

RHEB

Statin

TSC1 Hamartin

TSC2 Tuberin

2010  
1
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
[20388784] Cancer Res 70(8): 3287-98 (2010)
2008  
2
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
[18466115] Biochem J 412(2): 179-90 (2008)
2012  
3
Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome.
[22294621] Circulation 125(9): 1134-46 (2012)
2011  
4
Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin.
[21561413] Curr Drug Targets 12(8): 1223-31 (2011)
2009  
5
A complex interplay between Akt, TSC2 and the two mTOR complexes.
[19143635] Biochem Soc Trans 37(Pt 1): 217-22 (2009)

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All Medline data shown were primarily retrieved from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.


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