Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth Huang J; Manning BDBiochem J 2008[Jun]; 412 (2): 179-90TSC1 and TSC2 are the tumour-suppressor genes mutated in the tumour syndrome TSC (tuberous sclerosis complex). Their gene products form a complex that has become the focus of many signal transduction researchers. The TSC1-TSC2 (hamartin-tuberin) complex, through its GAP (GTPase-activating protein) activity towards the small G-protein Rheb (Ras homologue enriched in brain), is a critical negative regulator of mTORC1 (mammalian target of rapamycin complex 1). As mTORC1 activity controls anabolic processes to promote cell growth, it is exquisitely sensitive to alterations in cell growth conditions. Through numerous phosphorylation events, the TSC1-TSC2 complex has emerged as the sensor and integrator of these growth conditions, relaying signals from diverse cellular pathways to properly modulate mTORC1 activity. In the present review we focus on the molecular details of TSC1-TSC2 complex regulation and function as it relates to the control of Rheb and mTORC1.|*Cell Growth Processes[MESH]|*Genes, Tumor Suppressor[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Cell Cycle/physiology[MESH]|Humans[MESH]|Insulin-Like Growth Factor I/genetics/metabolism[MESH]|Insulin/metabolism[MESH]|Intercellular Signaling Peptides and Proteins/metabolism[MESH]|Molecular Sequence Data[MESH]|Monomeric GTP-Binding Proteins/genetics/metabolism[MESH]|Neuropeptides/genetics/metabolism[MESH]|Protein Kinases/genetics/metabolism[MESH]|Ras Homolog Enriched in Brain Protein[MESH]|Ribosomal Protein S6 Kinases/genetics/metabolism[MESH]|Sequence Alignment[MESH]|Signal Transduction/physiology[MESH]|TOR Serine-Threonine Kinases[MESH]|Transcription Factors/genetics/metabolism[MESH]|Tuberous Sclerosis Complex 1 Protein[MESH]|Tuberous Sclerosis Complex 2 Protein[MESH]|Tumor Suppressor Proteins/genetics/*metabolism[MESH] |
