suck pdf from google scholar
unlimited free pdf from europmc18459161    free
PDF from PMC    free
html from PMC    free
PDF vom PMID18459161 :   free
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text

  • DeepDyve
  • Pubget Overpricing

  • lüll
  • Mitochondrial copper metabolism and delivery to cytochrome c oxidase
  • Horn D; Barrientos A
  • IUBMB Life 2008[Jul]; 60 (7): 421-9
  • Metals are essential elements of all living organisms. Among them, copper is required for a multiplicity of functions including mitochondrial oxidative phosphorylation and protection against oxidative stress. Here we will focus on describing the pathways involved in the delivery of copper to cytochrome c oxidase (COX), a mitochondrial metalloenzyme acting as the terminal enzyme of the mitochondrial respiratory chain. The catalytic core of COX is formed by three mitochondrially-encoded subunits and contains three copper atoms. Two copper atoms bound to subunit 2 constitute the Cu(A) site, the primary acceptor of electrons from ferrocytochrome c. The third copper, Cu(B), is associated with the high-spin heme a(3) group of subunit 1. Recent studies, mostly performed in the yeast Saccharomyces cerevisiae, have provided new clues about 1) the source of the copper used for COX metallation; 2) the roles of Sco1p and Cox11p, the proteins involved in the direct delivery of copper to the Cu(A) and Cu(B) sites, respectively; 3) the action mechanism of Cox17p, a copper chaperone that provides copper to Sco1p and Cox11p; 4) the existence of at least four Cox17p homologues carrying a similar twin CX(9)C domain suggestive of metal binding, Cox19p, Cox23p, Pet191p and Cmc1p, that could be part of the same pathway; and 5) the presence of a disulfide relay system in the intermembrane space of mitochondria that mediates import of proteins with conserved cysteines motifs such as the CX(9)C characteristic of Cox17p and its homologues. The different pathways are reviewed and discussed in the context of both mitochondrial COX assembly and copper homeostasis.
  • |*Gene Expression Regulation[MESH]
  • |*Gene Expression Regulation, Fungal[MESH]
  • |Adenosine Triphosphate/metabolism[MESH]
  • |Binding Sites[MESH]
  • |Copper/*metabolism[MESH]
  • |Electron Transport Complex IV/*metabolism[MESH]
  • |Homeostasis[MESH]
  • |Humans[MESH]
  • |Ions[MESH]
  • |Ligands[MESH]
  • |Mitochondria/*metabolism[MESH]
  • |Models, Biological[MESH]
  • |Saccharomyces cerevisiae[MESH]

  • *{{pmid18459161}}
    *<b>[ Mitochondrial copper metabolism and delivery to cytochrome c oxidase ]</b> IUBMB Life 2008; 60(7) ; 421-9 Horn D; Barrientos A


    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    IUBMB Life

    421 7.60 2008