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  • Quantitating therapeutic disruption of tumor blood flow with intravital video microscopy
  • Iga AM; Sarkar S; Sales KM; Winslet MC; Seifalian AM
  • Cancer Res 2006[Dec]; 66 (24): 11517-9
  • Vascular-disrupting agents (VDA) kill tumor cells by selectively disrupting blood circulation in tumors. In vivo analysis of this intensely studied class of anticancer agents is invaluable for preclinical assessment of pharmacodynamic end points and effective therapeutic windows. In this review, we consider the role of intravital video microscopy in measuring tumor vascular response to VDAs, the potential of which lies in the opportunity to quantitate specific variables and to obtain real-time information on how VDAs affect tumor microcirculation.
  • |Angiogenesis Inhibitors/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Magnetic Resonance Imaging[MESH]
  • |Microscopy, Video/*methods[MESH]
  • |Neoplasms/*blood supply/*pathology[MESH]
  • |Neovascularization, Pathologic/*pathology/prevention & control[MESH]





  • *{{pmid17178842}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=17178842 Quantitating therapeutic disruption of tumor blood flow with intravital video microscopy ]</b> Cancer Res 2006; 66(24) ; 11517-9 Iga AM; Sarkar S; Sales KM; Winslet MC; Seifalian AM

        *17178842*

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    Cancer Res

    11517 24.66 2006