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  • Potential use of beta(3)-adrenoceptor antagonists in heart failure therapy
  • Moniotte S; Balligand JL
  • Cardiovasc Drug Rev 2002[Win]; 20 (1): 19-26
  • Recently, a functional, negatively inotropic, beta(3)-adrenoceptor was characterized in the human heart. Several studies now suggest that this receptor might play an important role in the pathophysiology of heart failure, by counterbalancing the effects of a beta(1)- and beta(2)-stimulation. Therefore, this review summarizes the rationale and effects of beta-adrenergic blockade in chronic heart failure and specifically addresses the question of the potential use of beta(3)-adrenoceptor antagonists in the treatment of heart failure and other pathophysiological conditions associated with a decreased cardiac contractility.
  • |*Adrenergic beta-3 Receptor Antagonists[MESH]
  • |Adrenergic beta-Antagonists/*therapeutic use[MESH]
  • |Animals[MESH]
  • |Autonomic Pathways/physiology[MESH]
  • |Heart Failure/*drug therapy/metabolism[MESH]
  • |Heart/drug effects/physiology[MESH]
  • |Humans[MESH]
  • |Receptors, Adrenergic, beta-3/physiology[MESH]
  • |Sympathetic Nervous System/physiology[MESH]





  • *{{pmid12070531}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=12070531 Potential use of beta(3)-adrenoceptor antagonists in heart failure therapy ]</b> Cardiovasc Drug Rev 2002; 20(1) ; 19-26 Moniotte S; Balligand JL

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    Cardiovasc Drug Rev

    19 1.20 2002