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2001 ; 14
(3
): 513-27
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Borna disease virus and human disease
#MMPMID11432811
Carbone KM
Clin Microbiol Rev
2001[Jul]; 14
(3
): 513-27
PMID11432811
show ga
The biology of Borna disease virus (BDV) strongly supports the likelihood of
human infection with BDV or a variant of BDV. Thus far, the evidence supporting
BDV infection in humans has initiated much controversy among basic and clinical
scientists; only time and additional research will support or refute the
hypothesis of human BDV infection. Until an assay of acceptable specificity and
sensitivity has been developed, validated, and used to document human BDV
infection, scientists cannot reasonably begin to associate BDV infection with
specific disease syndromes. Clinical studies seeking causal associations between
BDV infection and specific diseases must ensure the proper identification of the
BDV infection status of patients and control subjects by using a validated,
highly sensitive, and highly specific assay (or series of assays). For clinical
studies, a highly sensitive "screening" test followed by a highly specific
confirmatory test will be of significant benefit. Although it is possible to
formulate hypotheses about the clinical outcomes of human BDV infection based on
animal model work, to date no human disease has been causally linked to human BDV
infection. Scientists all over the world are actively pursuing these issues, and
with continuing advances in clinical and basic BDV research, the answers cannot
be far away.
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