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10.1007/s12539-021-00461-4 http://scihub22266oqcxt.onion/10.1007/s12539-021-00461-4 C8310681!8310681!34308530     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Interdiscip+Sci 2022 ; 14 (1): 64-79 Nephropedia Template TP {{tp|p=34308530|t=2022. Target-Based In Silico Screening for Phytoactive Compounds Targeting SARS-CoV-2 |pdf=|usr=}}{{34308530}} gab.com Text Target-Based In Silico Screening for Phytoactive Compounds Targeting SARS-CoV-2 JO: Interdiscip Sci http://www.kidney.de/pget.php?&tw=1&pmid=34308530 #FOAvip Abstract: Coronavirus disease 2019 (COVID-19), resulting from infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can cause severe and fatal pneumonia along with other life-threatening complications. The COVID-19 pandemic has taken a heavy toll on the healthcare system globally and has hit the economy hard in all affected countries. As a result, there is an unmet medical need for both the prevention and treatment of COVID-19 infection. Several herbal remedies have claimed to show promising clinical results, but the mechanisms of action are not clear. We set out to identify the anti-viral natural products of these herbal remedies that presumably inhibit the life cycle of SARS-CoV-2. Particularly we chose four key SARS-CoV-2 viral enzymes as targets: Papain-like protease, Main protease, RNA dependent RNA polymerase, and 2?-O-ribose methyltransferase, which were subjected to an unbiased in silico screening against a small molecule library of 33,765 compounds originating from herbs and medicinal plants. The small molecules were then ranked based on their free energy of fitting into the ?druggable? pockets on the surface of each target protein. We have analyzed the best ?fit? molecules and annotated them according to their plant sources and pharmacokinetic properties. Here we present a list of potential anti-viral ingredients of herbal remedies targeting SARS-CoV-2 and explore the potential mechanisms of action of these compounds as a framework for further development of chemoprophylaxis agents against COVID-19. Graphic abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s12539-021-00461-4. Twit Text FOAVip Target-Based In Silico Screening for Phytoactive Compounds Targeting SARS-CoV-2 ????Interdiscip Sci http://www.kidney.de/pget.php?&tw=1&pmid=34308530 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34308530 #FOAvip English Wikipedia <ref>{{Cite pmid|34308530}}</ref> Target-Based In Silico Screening for Phytoactive Compounds Targeting SARS-CoV-2 #MMPMID34308530 Zhao Y; Tian Y; Pan C; Liang A; Zhang W; Sheng Y Interdiscip Sci 2022[]; 14 (1): 64-79 PMID34308530show ga Abstract: Coronavirus disease 2019 (COVID-19), resulting from infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can cause severe and fatal pneumonia along with other life-threatening complications. The COVID-19 pandemic has taken a heavy toll on the healthcare system globally and has hit the economy hard in all affected countries. As a result, there is an unmet medical need for both the prevention and treatment of COVID-19 infection. Several herbal remedies have claimed to show promising clinical results, but the mechanisms of action are not clear. We set out to identify the anti-viral natural products of these herbal remedies that presumably inhibit the life cycle of SARS-CoV-2. Particularly we chose four key SARS-CoV-2 viral enzymes as targets: Papain-like protease, Main protease, RNA dependent RNA polymerase, and 2?-O-ribose methyltransferase, which were subjected to an unbiased in silico screening against a small molecule library of 33,765 compounds originating from herbs and medicinal plants. The small molecules were then ranked based on their free energy of fitting into the ?druggable? pockets on the surface of each target protein. We have analyzed the best ?fit? molecules and annotated them according to their plant sources and pharmacokinetic properties. Here we present a list of potential anti-viral ingredients of herbal remedies targeting SARS-CoV-2 and explore the potential mechanisms of action of these compounds as a framework for further development of chemoprophylaxis agents against COVID-19. Graphic abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s12539-021-00461-4. äTarget-Based In Silico Screening for Phytoactive Compounds Targeting S(epmc).pdf DeepDyve Pubget Overpricing