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10.1101/gad.348320.121

http://scihub22266oqcxt.onion/10.1101/gad.348320.121
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C8247602!8247602!34168039
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suck abstract from ncbi


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pmid34168039      Genes+Dev 2021 ; 35 (13-14): 1005-19
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  • Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication #MMPMID34168039
  • Burgess HM; Depledge DP; Thompson L; Srinivas KP; Grande RC; Vink EI; Abebe JS; Blackaby WP; Hendrick A; Albertella MR; Kouzarides T; Stapleford KA; Wilson AC; Mohr I
  • Genes Dev 2021[Jul]; 35 (13-14): 1005-19 PMID34168039show ga
  • In this study, Burgess et al. show that replication of SARS-CoV-2, the agent responsible for the COVID-19 pandemic, and a seasonal human ?-coronavirus, HCoV-OC43, can be suppressed by depletion of nuclear RNA methyltransferase METTL3 or cytoplasmic m6A reader proteins YTHDF1 and YTHDF3 and by a highly specific small molecule METTL3 inhibitor. Their findings establish that coronavirus RNAs are m6A-modified and host m6A pathway components control ?-coronavirus replication, and illustrate the therapeutic potential of inhibiting METTL3 to restrict coronavirus reproduction.
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