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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genes+Dev 2021 ; 35 (13-14): 1005-19 Nephropedia Template TP
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Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication #MMPMID34168039
Burgess HM; Depledge DP; Thompson L; Srinivas KP; Grande RC; Vink EI; Abebe JS; Blackaby WP; Hendrick A; Albertella MR; Kouzarides T; Stapleford KA; Wilson AC; Mohr I
Genes Dev 2021[Jul]; 35 (13-14): 1005-19 PMID34168039show ga
In this study, Burgess et al. show that replication of SARS-CoV-2, the agent responsible for the COVID-19 pandemic, and a seasonal human ?-coronavirus, HCoV-OC43, can be suppressed by depletion of nuclear RNA methyltransferase METTL3 or cytoplasmic m6A reader proteins YTHDF1 and YTHDF3 and by a highly specific small molecule METTL3 inhibitor. Their findings establish that coronavirus RNAs are m6A-modified and host m6A pathway components control ?-coronavirus replication, and illustrate the therapeutic potential of inhibiting METTL3 to restrict coronavirus reproduction.