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10.1016/j.ijbiomac.2021.02.071 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.02.071 C7871800!7871800!33577820     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2021 ; 177 (ä): 1-9 Nephropedia Template TP {{tp|p=33577820|t=2021. Potential drug targets of SARS-CoV-2: From genomics to therapeutics |pdf=|usr=}}{{33577820}} gab.com Text Potential drug targets of SARS-CoV-2: From genomics to therapeutics JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33577820 #FOAvip The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from China has become a global threat due to the continuous rise in cases of Coronavirus disease 2019 (COVID-19). The problem with COVID-19 therapeutics is due to complexity of the mechanism of the pathogenesis of this virus. In this review, an extensive analysis of genome architecture and mode of pathogenesis of SARS-CoV-2 with an emphasis on therapeutic approaches is performed. SARS-CoV-2 genome consists of a single, ~29.9 kb long RNA having significant sequence similarity to BAT-CoV, SARS-CoV and MERS-CoV genome. Two-third part of SARS-Cov-2 genome comprises of ORF (ORF1ab) resulting in the formation of 2 polyproteins, pp1a and pp1ab, later processed into 16 smaller non-structural proteins (NSPs). The four major structural proteins of SARS-CoV-2 are the spike surface glycoprotein (S), a small envelope (E), membrane (M), and nucleocapsid (N) proteins. S protein helps in receptor binding and membrane fusion and hence plays the most important role in the transmission of CoVs. Priming of S protein is done by serine 2 transmembrane protease and thus plays a key role in virus and host cell fusion. This review highlights the possible mechanism of action of SARS-CoV-2 to search for possible therapeutic options. Twit Text FOAVip Potential drug targets of SARS-CoV-2: From genomics to therapeutics ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33577820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33577820 #FOAvip English Wikipedia <ref>{{Cite pmid|33577820}}</ref> Potential drug targets of SARS-CoV-2: From genomics to therapeutics #MMPMID33577820 Shamsi A; Mohammad T; Anwar S; Amani S; Khan MS; Husain FM; Rehman MT; Islam A; Hassan MI Int J Biol Macromol 2021[Apr]; 177 (ä): 1-9 PMID33577820show ga The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from China has become a global threat due to the continuous rise in cases of Coronavirus disease 2019 (COVID-19). The problem with COVID-19 therapeutics is due to complexity of the mechanism of the pathogenesis of this virus. In this review, an extensive analysis of genome architecture and mode of pathogenesis of SARS-CoV-2 with an emphasis on therapeutic approaches is performed. SARS-CoV-2 genome consists of a single, ~29.9 kb long RNA having significant sequence similarity to BAT-CoV, SARS-CoV and MERS-CoV genome. Two-third part of SARS-Cov-2 genome comprises of ORF (ORF1ab) resulting in the formation of 2 polyproteins, pp1a and pp1ab, later processed into 16 smaller non-structural proteins (NSPs). The four major structural proteins of SARS-CoV-2 are the spike surface glycoprotein (S), a small envelope (E), membrane (M), and nucleocapsid (N) proteins. S protein helps in receptor binding and membrane fusion and hence plays the most important role in the transmission of CoVs. Priming of S protein is done by serine 2 transmembrane protease and thus plays a key role in virus and host cell fusion. This review highlights the possible mechanism of action of SARS-CoV-2 to search for possible therapeutic options. äPotential drug targets of SARS-CoV-2: From genomics to therapeutics (epmc).pdf DeepDyve Pubget Overpricing