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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ä-/-ä 2021 ; 22 (1): ä Nephropedia Template TP
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Susceptibility to the novel coronavirus disease (COVID-19) is associated with ABO and Rh blood groups: a case-control study from Afghanistan #MMPMIDC7781646
Saify K; Alborz MS; Saadat M
ä-/-ä 2021[]; 22 (1): ä PMIDC7781646show ga
Background: There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID-19; however, in the statistical analysis ABO and Rh blood groups have been considered separately. Therefore, the present case-control study was performed to determine the association of COVID-19 with ABO blood groups considering the Rh blood groups simultaneously. The study was conducted in Kunduz COVID-19 treatment specific center, Spin-Zar Hospital (Kunduz Province, North East Afghanistan). A total of 301 confirmed COVID-19 cases and 1039 healthy blood donors as control group were included in the study. Results: The Rh? phenotype strongly increased the risk of COVID-19 (OR = 2.97, 95% CI 1.86?3.89, P < 0.001). Although blood group A increased the risk of developing COVID-19, the association did not reach statistical significance. In analysis of the combination phenotypes, the A? blood group remarkably increased the risk of COVID-19 (OR = 7.24, 95% CI 3.62?14.4, P < 0.001). Multivariate analysis revealed that the interaction of Rh and ABO is significant (P < 0.013). Conclusion: These findings indicate that susceptibility to COVID-19 is strongly associated with A? blood group.