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2021 ; 84
(ä): 111103
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Micronutrients and bioactive substances: Their potential roles in combating
COVID-19
#MMPMID33450678
Keflie TS
; Biesalski HK
Nutrition
2021[Apr]; 84
(ä): 111103
PMID33450678
show ga
OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic is seriously
threatening public health and setting off huge economic crises across the world.
In the absence of specific drugs for COVID-19, there is an urgent need to look
for alternative approaches. Therefore, the aim of this paper was to review the
roles of micronutrients and bioactive substances as potential alternative
approaches in combating COVID-19. METHODS: This review was based on the
literature identified using electronic searches in different databases. RESULTS:
Vitamins (A, B, C, D, and E), minerals (selenium and zinc), and bioactive
substances from curcumin, echinacea, propolis, garlic, soybean, green tea, and
other polyphenols were identified as having potential roles in interfering with
spike glycoproteins, angiotensin converting enzyme 2, and transmembrane protease
serine 2 at the entry site, and inhibiting activities of papain-like protease, 3
chymotrypsin-like protease, and RNA-dependent RNA polymerase in the replication
cycle of severe acute respiratory syndrome coronavirus 2. Having
immunomodulating, antiinflammatory, antioxidant, and antiviral properties, such
micronutrients and bioactive substances are consequently promising alterative
nutritional approaches to combat COVID-19. CONCLUSIONS: The roles of
micronutrients and bioactive substances in the fight against COVID-19 are
exciting areas of research. This review may suggest directions for further study.