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2020 ; 2
(4
): 221-223
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
COVID-19: A pandemic that threatens physical and mental health by promoting
physical inactivity
#MMPMID34189487
Ali AM
; Kunugi H
Sports Med Health Sci
2020[Dec]; 2
(4
): 221-223
PMID34189487
show ga
Ever since the outbreak of Coronavirus disease 2019 (COVID-19) in late 2019, it
has killed millions of people worldwide. Even people not stricken by this disease
are not spared from its negative economic, social, and health-related drawbacks.
This commentary provides insight into the potential mechanisms involved in the
development of depression and emotional negativity escalating during the current
pandemic. In particular, preventive measures of COVID-19, such as staying at
home, are sedentarism measures that decrease physical activity. Physical
inactivity alters gut microbiome structure in a fashion that promotes gut
dysbiosis and flaring of systemic inflammation, leading to the buildup of body
fat. Obesity, which contributes to a trail of health-depleting disorders,
furthers gut microbial disintegration while fat tissue stimulates the release of
cytokines, promotes metabolic resistance, and alters signaling involved in the
production of antioxidants. As a result, the body gets flooded by toxic molecules
such pro-inflammatory mediators, free radicals, and advanced glycation end
products. These toxic molecules alter cellular function in all body tissues,
including those of the brain. Neuroinflammation is associated with progressive
declines in cognitive and motor functions along with dysregulation in emotions.
Counteracting the sedentarism enforced by the COVID-19 pandemic through the
participation in suitable indoors activities and the intake of healthy food is
likely to protect against or revert physiological impairments that may affect
people retreating to their homes during the current crisis, eventually restoring
physical and mental health.