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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Egypt+J+Med+Hum+Genet
2020 ; 21
(1
): 65
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An in silico LLPS perturbation approach in the design of a novel SARS-CoV-2 spike
receptor-binding domain inhibitor
#MMPMID38624529
Durojaye OA
; Sedzro DM
; Mushiana T
; Uzoeto HO
; Cosmas S
; Ajima JN
; Ibiang GO
Egypt J Med Hum Genet
2020[]; 21
(1
): 65
PMID38624529
show ga
The reversible process where a homogenous fluid de-mixes into two distinctively
separate liquid phases is referred to as LLPS (Liquid-liquid phase separation).
The resulting liquid is made up of one dilute phase and one condensed phase. An
increasing number of studies have shown that the liquid-liquid phase separation
is an important principle that underlies intracellular organization in biological
systems, forming liquid condensates without a membrane envelope, otherwise known
as MLOs (membraneless organelles). Such organelles include the P bodies,
nucleolus and stress granules. Moreover, the regulation of many other biological
processes such as signal transduction, chromatin rearrangement and RNA metabolism
have been linked to the liquid-liquid phase separation.