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  • An in silico LLPS perturbation approach in the design of a novel SARS-CoV-2 spike receptor-binding domain inhibitor #MMPMIDC7685779
  • Durojaye OA; Sedzro DM; Mushiana T; Uzoeto HO; Cosmas S; Ajima JN; Ibiang GO
  • ä-/-ä 2020[]; 21 (1): ä PMIDC7685779show ga
  • The reversible process where a homogenous fluid de-mixes into two distinctively separate liquid phases is referred to as LLPS (Liquid-liquid phase separation). The resulting liquid is made up of one dilute phase and one condensed phase. An increasing number of studies have shown that the liquid-liquid phase separation is an important principle that underlies intracellular organization in biological systems, forming liquid condensates without a membrane envelope, otherwise known as MLOs (membraneless organelles). Such organelles include the P bodies, nucleolus and stress granules. Moreover, the regulation of many other biological processes such as signal transduction, chromatin rearrangement and RNA metabolism have been linked to the liquid-liquid phase separation.
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  • suck abstract from ncbi

    ä 1.21 2020