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10.1186/s43042-020-00105-0

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suck abstract from ncbi


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pmid38624529
      Egypt+J+Med+Hum+Genet 2020 ; 21 (1 ): 65
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  • An in silico LLPS perturbation approach in the design of a novel SARS-CoV-2 spike receptor-binding domain inhibitor #MMPMID38624529
  • Durojaye OA ; Sedzro DM ; Mushiana T ; Uzoeto HO ; Cosmas S ; Ajima JN ; Ibiang GO
  • Egypt J Med Hum Genet 2020[]; 21 (1 ): 65 PMID38624529 show ga
  • The reversible process where a homogenous fluid de-mixes into two distinctively separate liquid phases is referred to as LLPS (Liquid-liquid phase separation). The resulting liquid is made up of one dilute phase and one condensed phase. An increasing number of studies have shown that the liquid-liquid phase separation is an important principle that underlies intracellular organization in biological systems, forming liquid condensates without a membrane envelope, otherwise known as MLOs (membraneless organelles). Such organelles include the P bodies, nucleolus and stress granules. Moreover, the regulation of many other biological processes such as signal transduction, chromatin rearrangement and RNA metabolism have been linked to the liquid-liquid phase separation.
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