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2020 ; 26
(6
): 485-492
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Why Are Patients With COVID-19 at Risk for Drug-Drug Interactions?
#MMPMID33275385
Preskorn SH
; Quadri S
J Psychiatr Pract
2020[Nov]; 26
(6
): 485-492
PMID33275385
show ga
The goal of this column is to provide information to health care professionals
about drug-drug interactions (DDIs) and why DDIs are important to consider in
those at serious risk of illness with Coronavirus Disease 2019 (COVID-19).
Important considerations discussed in this column include the frequency and
complexity of multiple medication use, particularly important for the older
patient who often has multiple comorbid illnesses. The column covers the
following issues: (1) Why patients at high risk for serious illness from COVID-19
are also at high risk for DDIs. (2) Application of results of
pharmacoepidemiological studies to the population at risk for serious COVID-19
illness. (3) Mechanisms underlying DDIs, frequency and potential complexity of
DDIs, and how DDIs can present clinically. (4) Methods for preventing or
mitigating DDIs. (5) An introduction to the University of Liverpool drug
interaction checker as a tool to reduce the risk of adverse DDIs while treating
patients for COVID-19. Commentary is also provided on issues related to specific
psychiatric and nonpsychiatric medications a patient may be taking. A subsequent
column will focus on DDIs between psychiatric medications and emerging COVID-19
treatments, as a detailed discussion of that topic is beyond the scope of this
column.
|*COVID-19 Drug Treatment
[MESH]
|*Drug-Related Side Effects and Adverse Reactions/prevention & control
[MESH]
|*Polypharmacy
[MESH]
|Adolescent
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Comorbidity
[MESH]
|Drug Interactions
[MESH]
|Humans
[MESH]
|Middle Aged
[MESH]
|Risk
[MESH]
|Substance Abuse Detection/*statistics & numerical data
[MESH]