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10.1007/978-981-15-7918-9_7 http://scihub22266oqcxt.onion/10.1007/978-981-15-7918-9_7 C7677609!7677609!C7677609     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Novel+Coronavirus+2019 ä ; ä (ä): 53-61 Nephropedia Template TP {{tp|p=C7677609|t=ä. Evolutionary and Structural Studies of NCoV and SARS CoV-Spike proteins and their association with ACE2 Receptor |pdf=|usr=}}{{C7677609}} gab.com Text Evolutionary and Structural Studies of NCoV and SARS CoV-Spike proteins and their association with ACE2 Receptor JO: Novel Coronavirus 2019 http://www.kidney.de/pget.php?&tw=1&pmid=C7677609 #FOAvip Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/Novel Corona Virus Disease-19 (nCOVID-19)/COVID-19 has only been discovered recently, and so our understanding of the disease epidemiology is continuously evolving. WHO has declared it a worldwide pandemic with high morbidity and significant mortality, hence it has been announced as the global health and wealth emergency. At present there is no any specific therapy available to fight against this virus, hence the drug repositioning is the most challenging to entire scientific community. The aim of this study is to determine the mutation(s) in the sequence of the spike protein, which plays a significant role in transmission from human to human. By using bioinformatics approach first we analyzed spike protein sequence of four nearest coronavirus family that include COVID-19, bat coronavirus RaTG13, pangolian coronavirus and SARS CoV, to determine phylogenetic distance between them. The homology modeling of COVID-19 spike protein has been done by iTASSER. and the protein-protein docking with human receptor ACE2 by Frodock web based docking tool showing the less binding energy of COVID-19 (?12.7 kcal/mol) in comparison with SARS CoV (10.3 kcal/mol). Further, the superimposed structure of COVID-19 and SARS CoV viruses has been performed to find the mutational site in association with human ACE2 protein. The extensive and detailed computational analyses approaches help to identify conserved region of COVID-19 and SARS CoV. Hence, our present data might help to identify potential target site and to develop antiviral drugs/vaccine to combat this pandemic. Twit Text FOAVip Evolutionary and Structural Studies of NCoV and SARS CoV-Spike proteins and their association with ACE2 Receptor ????Novel Coronavirus 2019 http://www.kidney.de/pget.php?&tw=1&pmid=C7677609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=C7677609 #FOAvip English Wikipedia <ref>{{Cite pmid|C7677609}}</ref> Evolutionary and Structural Studies of NCoV and SARS CoV-Spike proteins and their association with ACE2 Receptor #MMPMIDC7677609 Kumar A; Saxena AK; Lee GG(; Kashyap A; Jyothsna G Novel Coronavirus 2019 ä[]; ä (ä): 53-61 PMIDC7677609show ga Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/Novel Corona Virus Disease-19 (nCOVID-19)/COVID-19 has only been discovered recently, and so our understanding of the disease epidemiology is continuously evolving. WHO has declared it a worldwide pandemic with high morbidity and significant mortality, hence it has been announced as the global health and wealth emergency. At present there is no any specific therapy available to fight against this virus, hence the drug repositioning is the most challenging to entire scientific community. The aim of this study is to determine the mutation(s) in the sequence of the spike protein, which plays a significant role in transmission from human to human. By using bioinformatics approach first we analyzed spike protein sequence of four nearest coronavirus family that include COVID-19, bat coronavirus RaTG13, pangolian coronavirus and SARS CoV, to determine phylogenetic distance between them. The homology modeling of COVID-19 spike protein has been done by iTASSER. and the protein-protein docking with human receptor ACE2 by Frodock web based docking tool showing the less binding energy of COVID-19 (?12.7 kcal/mol) in comparison with SARS CoV (10.3 kcal/mol). Further, the superimposed structure of COVID-19 and SARS CoV viruses has been performed to find the mutational site in association with human ACE2 protein. The extensive and detailed computational analyses approaches help to identify conserved region of COVID-19 and SARS CoV. Hence, our present data might help to identify potential target site and to develop antiviral drugs/vaccine to combat this pandemic. äEvolutionary and Structural Studies of NCoV and SARS CoV-Spike protein(epmc).pdf DeepDyve Pubget Overpricing