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(2
): 108-17
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Influence of cardiovascular disease and cardiovascular risk factors in COVID-19
patients Data from a large prospective Spanish cohort
#MMPMIDC7670893
García-Guimaraes M
; Mojón D
; Calvo A
; Izquierdo A
; Belarte-Tornero L
; Salvatella N
; Llagostera M
; Negrete A
; Mas-Stachurska A
; Ruiz S
; Valdivielso S
; Ribas N
; Marrugat J
; Farré N
; Vaquerizo B
ä-/-ä 2021[Apr]; 56
(2
): 108-17
PMIDC7670893
show ga
INTRODUCTION AND OBJECTIVES: Coronavirus disease 2019 (COVID-19) has become a
pandemic. Retrospective data showed worse outcomes in patients with
cardiovascular disease (CVD) and cardiovascular (CV) risk factors. Our aim was to
evaluate the link between CVD and CV risk factors and in-hospital outcomes in
COVID-19 patients. METHODS: We designed a prospective registry that included
consecutive COVID-19 patients admitted at our institution. The inclusion period
was from 27 February to 7 April 2020. Clinical outcomes were monitored up to 2
May 2020. RESULTS: A total of 876 patients were included. Mean age was 62 ± 18
years old; 47% were > 65 years of age. A total of 69% of patients had at least
one CV risk factor; 15% of the patients had previous history of CVD. Patients
with previous CVD were significantly older (77 ± 11 vs 60 ± 18 years old;
P < .01), with a higher proportion of men (64 vs 54%; P = .021) and showed a
higher proportion of rise in both high-sensitivity cardiac-specific troponin-T
(hs-cTnT) (78 vs 27%; P < .01) and N-terminal pro-B-type natriuretic peptide
(NT-proBNP) (74 vs 29%; P < .01) on admission. Those patients with CV risk
factors were also significantly older (68 ± 16 vs 49 ± 16 years old; P < .01),
showing a higher percentage of patients fulfilling acute distress respiratory
syndrome criteria (28 vs 21%; P = .021) and more need of mechanical ventilation
(9 vs 4%; P < .01). Levels of hs-cTnT (44 vs 9%; P < .01) and NT-proBNP (43 vs
15%; P < .01) were more frequently elevated in patients with CV risk factors.
Risk of death was significantly higher in patients with CVD (33 vs 8%; P < .01)
or CV risk factors (16 vs 1%; P < .01). We found age > 65 years old (OR, 15;
95%CI, 5?43), chronic congestive heart failure (OR, 3.27; 95%CI, 1.38?7.72) and
chronic kidney disease (OR, 8.55; 95%CI, 1.47?5.46) as independent predictors of
death. CONCLUSIONS: In patients admitted for COVID-19, CVD or CV risk factors are
associated with an increased risk of death during hospitalization. We found that
older age, history of congestive heart failure and chronic kidney disease are
independent predictors of death in COVID-19.