Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1093/jalm/jfaa187

http://scihub22266oqcxt.onion/10.1093/jalm/jfaa187
suck pdf from google scholar
C7665530!7665530!33674879
unlimited free pdf from europmc33674879    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid33674879      J+Appl+Lab+Med ä ; ä (ä): ä
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Analytic Sensitivity of Three Nucleic Acid Detection Assays in Diagnosis of SARS-CoV-2 Infection #MMPMID33674879
  • Sieker JT; Horowitz C; Hu CTK; Lacombe-Daphnis M; Chirokas B; Pina C; Heger NE; Rabson AR; Zhou M; Bogen SA; Horowitz GL
  • J Appl Lab Med ä[]; ä (ä): ä PMID33674879show ga
  • Background: Detection of SARS-CoV-2 by reverse transcriptase polymerase chain reaction is the primary method to diagnose Coronavirus Infectious Disease 2019 (COVID-19). Yet, the analytical sensitivity required is not well defined and it is unclear how available assays compare. Methods: For the Abbott RealTime SARS-CoV-2 assay (Abbott Molecular Inc.; abbreviated as m2000), we determined that it could detect viral concentrations as low as 26 copies/mL, we defined the relationship between cycle number and viral concentrations, and we tested naso- and oropharyngeal swab specimens from N?=?8,538 consecutive individuals. Using the m2000 as a reference assay method, we described the distribution of viral concentrations in these patients. We then used selected clinical specimens to determine the positive percent agreement of two other assays with more rapid turnaround times (Cepheid Xpert Xpress (Cepheid Inc.; GeneXpert, N?=?27 specimens) and a laboratory developed test on the Luminex ARIES system (Luminex Corporation; ARIES LDT, N?=?50)) as a function of virus concentrations, from which we projected their false negative rates in our patient population. Results: SARS-CoV-2 was detected in 27% (95% confidence interval of 26-28%) of all specimens. Estimated viral concentrations were widely distributed and 17% (16-19%) of positive individuals had viral concentrations below 845 copies/mL. Positive percent agreement was strongly related to viral concentration and reliable detection (i.e. ?95%), was observed at concentrations >100 copies/mL for the GeneXpert but not the ARIES LDT, corresponding to projected false negative rates of 4% (0-21%) and 27% (11-46%), respectively. Conclusions: Substantial proportions of clinical specimens have low to moderate viral concentrations and may be missed by methods with lesser analytical sensitivity.
  • ä


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box