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Expresser phenotype determines ABO(H) blood group antigen loading on platelets
and von Willebrand factor
#MMPMID33110150
O'Donghaile D
; Jenkins PV
; McGrath RT
; Preston L
; Field SP
; Ward SE
; O'Sullivan JM
; O'Donnell JS
Sci Rep
2020[Oct]; 10
(1
): 18366
PMID33110150
show ga
ABO blood group is associated with cardiovascular disease, with significantly
lower risk in blood group O individuals. ABO(H) blood group determinants are
expressed on different glycoproteins on platelet surfaces. In addition, ABO(H)
structures are also present on VWF glycans. These ABO(H) carbohydrates influence
both platelet and VWF function. Previous studies have reported that approximately
5-10% of normal blood donors express abnormally high or low levels of A or B
blood group antigens on their platelet surfaces (high expresser phenotype, HXP or
low expresser phenotype, LXP respectively). In this study, the biological effects
of the ABO Expresser phenotype were investigated. ABO(H) expression on platelets
and plasma VWF was studied in a series of 541 healthy blood donors. Overall, 5.6%
of our study cohort were classified as HXP, whilst 4.4% satisfied criteria for
LXP. We demonstrate that genotype at the ABO blood group locus plays a critical
role in modulating the platelet HXP phenotype. In particular, A(1)A(1) genotype
is a major determinant of ABO high-expresser trait. Our data further show that
ABH loading on VWF is also affected by ABO expresser phenotype. Consequently, A
antigen expression on VWF was significantly elevated in HXP individuals and
moderately reduced in LXP subjects (P?
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