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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Pharmacol+Transl+Sci 2020 ; 3 (6): 1165-75 Nephropedia Template TP
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Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles #MMPMID33330839
Chen CZ; Xu M; Pradhan M; Gorshkov K; Petersen JD; Straus MR; Zhu W; Shinn P; Guo H; Shen M; Klumpp-Thomas C; Michael SG; Zimmerberg J; Zheng W; Whittaker GR
ACS Pharmacol Transl Sci 2020[Dec]; 3 (6): 1165-75 PMID33330839show ga
While vaccine development will hopefully quell the global pandemic of COVID-19 caused by SARS-CoV-2, small molecule drugs that can effectively control SARS-CoV-2 infection are urgently needed. Here, inhibitors of spike (S) mediated cell entry were identified in a high throughput screen of an approved drugs library with SARS-S and MERS-S pseudotyped particle entry assays. We discovered six compounds (cepharanthine, abemaciclib, osimertinib, trimipramine, colforsin, and ingenol) to be broad spectrum inhibitors for spike-mediated entry. This work could contribute to the development of effective treatments against the initial stage of viral infection and provide mechanistic information that might aid the design of new drug combinations for clinical trials for COVID-19 patients.