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10.2217/fvl-2020-0119

http://scihub22266oqcxt.onion/10.2217/fvl-2020-0119
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C7543042!7543042!C7543042
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suck abstract from ncbi


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pmidC7543042      Future+Virol ä ; ä (ä): ä
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  • In silico analysis of protein/peptide-based inhalers against SARS-CoV-2 #MMPMIDC7543042
  • Salman S; Shah FH; Chaudhry M; Tariq M; Akbar MY; Adnan M
  • Future Virol ä[]; ä (ä): ä PMIDC7543042show ga
  • Aim: Peptide/protein-based inhalers are excessively used to treat respiratory disorders. The molecular docking was performed for these inhalers including human neutralizing S230 light chain-antibody (monoclonal antibodies [mAbs]), alpha-1-antitrypsin (AAT), short-palate-lung and nasal-epithelial clone-1-derived peptides (SPLUNC1) and dornase-alfa (DA) against spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to assess their inhibitory activity. Materials & methods: HawkDock was used to dock these biologics against SARS-CoV-2 spike-glycoprotein. Results: Results showed that DA, AAT and mAb were quite active against spike glycoprotein with a binding free energy of -26.35 and -22.94 kcal/mol. Conclusion: mAB and AAT combined with DA can be used in the treatment of coronavirus disease of 2019 as a potential anti-SARS-CoV-2 agent.
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