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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Korean+Med+Sci
2020 ; 35
(29
): e269
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English Wikipedia
IgG Seroprevalence of COVID-19 among Individuals without a History of the
Coronavirus Disease Infection in Daegu, Korea
#MMPMID32715672
Song SK
; Lee DH
; Nam JH
; Kim KT
; Do JS
; Kang DW
; Kim SG
; Cho MR
J Korean Med Sci
2020[Jul]; 35
(29
): e269
PMID32715672
show ga
BACKGROUND: Seroprevalence studies of coronavirus disease 2019 (COVID-19) from
many countries have shown that the number of undiagnosed missing cases is much
larger than that of confirmed cases, irrespective of seroprevalence levels.
Considering the strategy of Korea entailing massive testing and contact tracing
from the beginning of epidemic, the number of undiagnosed missing cases in Korea
may be negligible. This study was conducted to estimate the seroprevalence of
COVID-19 among individuals who were never diagnosed with COVID-19 in Daegu, the
epicenter of COVID-19 epidemic in Korea. METHODS: Serologic testing for
immunoglobulin G antibody based on immunochromatographic assay was conducted in
103 patients and 95 guardians aged 18 to 82 years without any history of COVID-19
diagnosis, who visited outpatient clinics of a single university-affiliated
hospital from May 25 to June 5, 2020. RESULTS: The estimated seroprevalence was
7.6% (95% confidence interval, 4.3%-12.2%) with 15 positive cases. Among them,
only one had a polymerase chain reaction (PCR)-confirmed case among their close
contacts and 13 did not experience COVID-19-related symptoms. Seroprevalence was
similar between patients and guardians. Based on this figure, the number of
undiagnosed missing cases in Daegu was estimated to be a dozen times more than
the number of confirmed cases based on PCR testing. CONCLUSION: Despite the
limitation of a small and unrepresentative sample, this is the first study on
seroprevalence of COVID-19 in Korea. Our study suggested that the number of
undiagnosed missing cases was substantial even with the stringent strategy
adopted in Korea, similar to that of other countries.