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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Eur+J+Nucl+Med+Mol+Imaging
2021 ; 48
(1
): 260-268
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English Wikipedia
COVID-19 pneumonia: relationship between inflammation assessed by whole-body FDG
PET/CT and short-term clinical outcome
#MMPMID32712702
Dietz M
; Chironi G
; Claessens YE
; Farhad RL
; Rouquette I
; Serrano B
; Nataf V
; Hugonnet F
; Paulmier B
; Berthier F
; Keita-Perse O
; Giammarile F
; Perrin C
; Faraggi M
Eur J Nucl Med Mol Imaging
2021[Jan]; 48
(1
): 260-268
PMID32712702
show ga
PURPOSE: [18F]-2-Fluoro-2-deoxy-D-glucose PET/CT (FDG PET/CT) is a sensitive and
quantitative technic for detecting inflammatory process. Glucose uptake is
correlated with an increased anaerobic glycolysis seen in activated inflammatory
cells such as monocytes, lymphocytes, and granulocytes. The aim of the study was
to assess the inflammatory status at the presumed peak of the inflammatory phase
in non-critically ill patients requiring admission for COVID-19. METHODS:
Patients admitted with COVID-19 were prospectively enrolled. FDG PET/CT was
performed from day 6 to day 14 of the onset of symptoms. Depending on FDG PET/CT
findings, patients' profiles were classified as "inflammatory" or "low
inflammatory." FDG PET/CT data were compared with chest CT evolution and
short-term clinical outcome. All inflammatory sites were reported to screen
potential extra-pulmonary tropism. RESULTS: Thirteen patients were included.
Maximum standardized uptake values ranged from 4.7 to 16.3 in lungs. All patients
demonstrated increased mediastinal lymph nodes glucose uptake. Three patients
(23%) presented mild nasopharyngeal, two patients (15%) bone marrow, and five
patients (38%) splenic mild increase in glucose uptake. No patient had
significant digestive focal or segmental glucose uptake. There was no significant
physiological myocardial glucose uptake in all patients except one. There was no
correlation between PET lung inflammatory status and chest CT evolution or
short-term clinical outcome. CONCLUSION: Inflammatory process at the presumed
peak of the inflammatory phase in COVID-19 patients is obvious in FDG PET/CT
scans. Glucose uptake is heterogeneous and typically focused on lungs. TRIAL
REGISTRATION: NCT04441489. Registered 22 June 2020 (retrospectively registered).