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2020 ; 27
(33
): 42115-42123
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Higher body mass index is an important risk factor in COVID-19 patients: a
systematic review and meta-analysis
#MMPMID32710359
Malik VS
; Ravindra K
; Attri SV
; Bhadada SK
; Singh M
Environ Sci Pollut Res Int
2020[Nov]; 27
(33
): 42115-42123
PMID32710359
show ga
Globally, both obesity and underweight are severe health risks for various
diseases. The current study systematically examined the emerging evidence to
identify an association between body mass index (BMI) and COVID-19 disease
outcome. Online literature databases (e.g., Google Scholar, PubMed, MEDLINE,
EMBASE, Scopus, Medrixv and BioRixv) were screened following standard search
strategy having the appropriate keyword such as "Obesity", "Underweight", "BMI",
"Body Mass Index", "2019-nCov", "COVID-19, "novel coronavirus", "coronavirus
disease". Studies published till 20(th) April 2020 were included without language
restriction. These studies include case reports, case series, cohort, and any
other which reported BMI, overweight/obesity or underweight, and its complication
with COVID-19 disease. This study observed COVID-19 infection among BMI < 25
kg/m(2) with prevalence of 0.60 (95%CI: 0.34-0.86, I(2) = - 76.77) as compared to
the 0.34 (95%CI: 0.23-0.44, I(2) = 53.45% heterogeneity) having BMI > 25 kg/m(2).
The results of the current study show that BMI plays a significant role in
COVID-19 severity in all age groups, especially the older individuals. A panel of
doctors and nursing staff should review COVID-19 patients with higher BMI with
other co-morbidities (diabetes and hypertension), and they should be given
increased vigilance, priority in testing, and treatment to control the associated
co-morbidities. Further, the COVID-19 patients whose illness entered 7-10 days,
age > 50 years, and elevated CRP levels should be given additional medical
considerations. Our finding showed that the population and patients with high BMI
have moderate to high risk of medical complications with COVID-19, and hence,
their health status should be monitored more frequently including monitoring of
blood pressure and blood glucose.
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