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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Aging+(Albany+NY)
2020 ; 12
(13
): 12504-12516
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gab.com Text
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Risk factors influencing the prognosis of elderly patients infected with
COVID-19: a clinical retrospective study in Wuhan, China
#MMPMID32651993
Gao S
; Jiang F
; Jin W
; Shi Y
; Yang L
; Xia Y
; Jia L
; Wang B
; Lin H
; Cai Y
; Xia Z
; Peng J
Aging (Albany NY)
2020[Jul]; 12
(13
): 12504-12516
PMID32651993
show ga
The mortality rate of elderly patients with Coronavirus Disease 2019 (COVID-19)
was significantly higher than the overall mortality rate. However, besides age,
leading death risk factors for the high mortality in elderly patients remain
unidentified. This retrospective study included 210 elderly COVID-19 patients
(aged ? 65 years), of whom 175 patients were discharged and 35 died. All deceased
patients had at least one comorbidity. A significantly higher proportion of
patients in the deceased group had cardiovascular diseases (49% vs. 20%),
respiratory diseases (51% vs. 11%), chronic kidney disease (29% vs. 5%) and
cerebrovascular disease (20% vs. 3%) than that in the discharged group. The
median levels of C-reactive protein (125.8mg/L vs. 9.3mg/L) and blood urea
nitrogen (7.2mmol/L vs. 4.4mmol/L) were significantly higher and median
lymphocyte counts (0.7×10(9)/L vs. 1.1×10(9)/L) significantly lower in the
deceased group than those in the discharged group. The survival curve analysis
showed that higher C-reactive protein (?5mg/L) plus any other abnormalities of
lymphocyte, blood urea nitrogen or lactate dehydrogenase significantly predicted
poor prognosis of COVID-19 infected elderly patients. This study revealed that
the risk factors for the death in these elderly patients included comorbidities,
increased levels of C-reactive protein and blood urea nitrogen, and lymphopenia
during hospitalization.