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10.1016/j.ijantimicag.2020.106110

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C7377803!7377803 !32712332
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suck abstract from ncbi


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pmid32712332
      Int+J+Antimicrob+Agents 2020 ; 56 (3 ): 106110
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  • Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patients #MMPMID32712332
  • Cheng A ; Hu L ; Wang Y ; Huang L ; Zhao L ; Zhang C ; Liu X ; Xu R ; Liu F ; Li J ; Ye D ; Wang T ; Lv Y ; Liu Q
  • Int J Antimicrob Agents 2020[Sep]; 56 (3 ): 106110 PMID32712332 show ga
  • The crude mortality rate in critical pneumonia cases with coronavirus disease 2019 (COVID-19) reaches 49%. This study aimed to test whether levels of blood urea nitrogen (BUN) in combination with D-dimer were predictors of in-hospital mortality in COVID-19 patients. The clinical characteristics of 305 COVID-19 patients were analysed and were compared between the survivor and non-survivor groups. Of the 305 patients, 85 (27.9%) died and 220 (72.1%) were discharged from hospital. Compared with discharged cases, non-survivor cases were older and their BUN and D-dimer levels were significantly higher (P < 0.0001). Least absolute shrinkage and selection operator (LASSO) and multivariable Cox regression analyses identified BUN and D-dimer levels as independent risk factors for poor prognosis. Kaplan-Meier analysis showed that elevated levels of BUN and D-dimer were associated with increased mortality (log-rank, P < 0.0001). The area under the curve for BUN combined with D-dimer was 0.94 (95% CI 0.90-0.97), with a sensitivity of 85% and specificity of 91%. Based on BUN and D-dimer levels on admission, a nomogram model was developed that showed good discrimination, with a concordance index of 0.94. Together, initial BUN and D-dimer levels were associated with mortality in COVID-19 patients. The combination of BUN ? 4.6 mmol/L and D-dimer ? 0.845 ?g/mL appears to identify patients at high risk of in-hospital mortality, therefore it may prove to be a powerful risk assessment tool for severe COVID-19 patients.
  • |*Blood Urea Nitrogen [MESH]
  • |Aged [MESH]
  • |Area Under Curve [MESH]
  • |Betacoronavirus/*pathogenicity [MESH]
  • |Biomarkers/blood [MESH]
  • |COVID-19 [MESH]
  • |Coronavirus Infections/blood/*diagnosis/*mortality/virology [MESH]
  • |Female [MESH]
  • |Fibrin Fibrinogen Degradation Products/*metabolism [MESH]
  • |Hospital Mortality [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Pandemics [MESH]
  • |Pneumonia, Viral/blood/*diagnosis/*mortality/virology [MESH]
  • |Prognosis [MESH]
  • |Proportional Hazards Models [MESH]
  • |Retrospective Studies [MESH]
  • |Risk [MESH]


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