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10.1007/s40520-020-01653-6 http://scihub22266oqcxt.onion/10.1007/s40520-020-01653-6 C7377312!7377312 !32705587     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32705587 &cmd=llinks): Failed to open stream: HTTP request failed! 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COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants |pdf=|usr=}}{{32705587 }} gab.com Text COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants JO: Aging Clin Exp Res http://www.kidney.de/pget.php?&tw=1&pmid=32705587 #FOAvip BACKGROUND: Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease. AIMS: We investigated, in the UK Biobank, whether frailty and multimorbidity were associated with risk of hospitalisation with COVID-19. METHODS: 502,640 participants aged 40-69 years at baseline (54-79 years at COVID-19 testing) were recruited across UK during 2006-10. A modified assessment of frailty using Fried's classification was generated from baseline data. COVID-19 test results (England) were available for 16/03/2020-01/06/2020, mostly taken in hospital settings. Logistic regression was used to discern associations between frailty, multimorbidity and COVID-19 diagnoses, after adjusting for sex, age, BMI, ethnicity, education, smoking and number of comorbidity groupings, comparing COVID-19 positive, COVID-19 negative and non-tested groups. RESULTS: 4510 participants were tested for COVID-19 (positive?=?1326, negative?=?3184). 497,996 participants were not tested. Compared to the non-tested group, after adjustment, COVID-19 positive participants were more likely to be frail (OR?=?1.4 [95%CI?=?1.1, 1.8]), report slow walking speed (OR?=?1.3 [1.1, 1.6]), report two or more falls in the past year (OR?=?1.3 [1.0, 1.5]) and be multimorbid (??4 comorbidity groupings vs 0-1: OR?=?1.9 [1.5, 2.3]). However, similar strength of associations were apparent when comparing COVID-19 negative and non-tested groups. However, frailty and multimorbidity were not associated with COVID-19 diagnoses, when comparing COVID-19 positive and COVID-19 negative participants. DISCUSSION AND CONCLUSIONS: Frailty and multimorbidity do not appear to aid risk stratification, in terms of positive versus negative results of COVID-19 testing. Investigation of the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease is urgently needed. Twit Text FOAVip COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants ????Aging Clin Exp Res http://www.kidney.de/pget.php?&tw=1&pmid=32705587 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32705587 #FOAvip English Wikipedia <ref>{{Cite pmid|32705587 }}</ref> COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants #MMPMID32705587 Woolford SJ ; D'Angelo S ; Curtis EM ; Parsons CM ; Ward KA ; Dennison EM ; Patel HP ; Cooper C ; Harvey NC Aging Clin Exp Res 2020[Sep]; 32 (9 ): 1897-1905 PMID32705587 show ga BACKGROUND: Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease. AIMS: We investigated, in the UK Biobank, whether frailty and multimorbidity were associated with risk of hospitalisation with COVID-19. METHODS: 502,640 participants aged 40-69 years at baseline (54-79 years at COVID-19 testing) were recruited across UK during 2006-10. A modified assessment of frailty using Fried's classification was generated from baseline data. COVID-19 test results (England) were available for 16/03/2020-01/06/2020, mostly taken in hospital settings. Logistic regression was used to discern associations between frailty, multimorbidity and COVID-19 diagnoses, after adjusting for sex, age, BMI, ethnicity, education, smoking and number of comorbidity groupings, comparing COVID-19 positive, COVID-19 negative and non-tested groups. RESULTS: 4510 participants were tested for COVID-19 (positive?=?1326, negative?=?3184). 497,996 participants were not tested. Compared to the non-tested group, after adjustment, COVID-19 positive participants were more likely to be frail (OR?=?1.4 [95%CI?=?1.1, 1.8]), report slow walking speed (OR?=?1.3 [1.1, 1.6]), report two or more falls in the past year (OR?=?1.3 [1.0, 1.5]) and be multimorbid (??4 comorbidity groupings vs 0-1: OR?=?1.9 [1.5, 2.3]). However, similar strength of associations were apparent when comparing COVID-19 negative and non-tested groups. However, frailty and multimorbidity were not associated with COVID-19 diagnoses, when comparing COVID-19 positive and COVID-19 negative participants. DISCUSSION AND CONCLUSIONS: Frailty and multimorbidity do not appear to aid risk stratification, in terms of positive versus negative results of COVID-19 testing. Investigation of the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease is urgently needed. |*Clinical Laboratory Techniques/methods/statistics & numerical data [MESH] |*Coronavirus Infections/diagnosis/epidemiology [MESH] |*Frailty/diagnosis/epidemiology [MESH] |*Multimorbidity [MESH] |*Musculoskeletal Diseases/diagnosis/epidemiology [MESH] |*Pandemics [MESH] |*Pneumonia, Viral/diagnosis/epidemiology [MESH] |Aged [MESH] |Betacoronavirus/isolation & purification [MESH] |COVID-19 [MESH] |COVID-19 Testing [MESH] |Female [MESH] |Geriatric Assessment/methods/statistics & numerical data [MESH] |Humans [MESH] |Male [MESH] |Prognosis [MESH] |Prospective Studies [MESH] |Risk Assessment/methods [MESH] |Risk Factors [MESH] |SARS-CoV-2 [MESH]COVID-19 and associations with frailty and multimorbidity: a prospecti(epmc).pdf DeepDyve Pubget Overpricing