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Confronting and mitigating the risk of COVID-19 associated pulmonary aspergillosis #MMPMID32703771
Armstrong-James D; Youngs J; Bicanic T; Abdolrasouli A; Denning DW; Johnson E; Mehra V; Pagliuca T; Patel B; Rhodes J; Schelenz S; Shah A; van de Veerdonk FL; Verweij PE; White PL; Fisher MC
Eur Respir J 2020[Oct]; 56 (4): ä PMID32703771show ga
The coronavirus disease 2019 (COVID-19) virus caused a wide spectrum of disease in healthy individuals, as well as those with common comorbidities [1]. Severe COVID-19 is characterised by acute respiratory distress syndrome (ARDS) secondary to viral pneumonitis, treatment of which may require mechanical ventilation or extracorporeal membrane oxygenation [2]. Clinicians are alert to the possibility of bacterial co-infection as a complication of lower respiratory tract viral infection; for example, a recent review found that 72% of patients with COVID-19 received antimicrobial therapy [3]. However, the risk of fungal co-infection, in particular COVID-19 associated pulmonary aspergillosis (CAPA), remains underappreciated.