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2020 ; 9
(1
): 161
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gab.com Text
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Maternal and perinatal outcomes and pharmacological management of Covid-19
infection in pregnancy: a systematic review protocol
#MMPMID32682444
Thomas B
; Pallivalapila A
; El Kassem W
; Tarannum A
; Al Hail F
; Rijims M
; Parappil H
; Bayo AI
; Ahmad S
; Nazar Z
; Stewart D
; Al Hail M
Syst Rev
2020[Jul]; 9
(1
): 161
PMID32682444
show ga
BACKGROUND: Over 4.2 million confirmed cases and more than 285,000 deaths,
COVID-19 pandemic continues to harm significant number of people worldwide.
Several studies have reported the impact of COVID-19 in general population;
however, there is scarcity of information related to pharmacological management
and maternal and perinatal outcomes during the pandemic. Altered physiological,
anatomical, and immunological response during pregnancy makes it more susceptible
to infections. Furthermore, during pregnancy, a woman undergoes multiple
interactions with the health care system that increases her chance of getting
infected; therefore, managing pregnant population presents a unique challenge.
RESEARCH QUESTIONS: This systematic review seeks to answer the following
questions in relation to COVID-19: What are the different clinical
characteristics presented in maternal and perinatal population? What are the
different maternal and perinatal outcome measures reported? What are the distinct
therapeutic interventions reported to treat COVID-19? Is it safe to use
"medications" used in the treatment of COVID-19 during antenatal, perinatal,
postnatal, and breastfeeding? METHOD: The search will follow a comprehensive,
sequential three step search strategy. Several databases relevant to COVID-19 and
its impact on pregnancy including Medline, CINAHL, and LitCovid will be searched
from the inception of the disease until the completion of data collection. The
quality of this search strategy will be assessed using Peer Review of Electronic
Search Strategies Evidence-Based Checklist (PRESS EBC). An eligibility form will
be developed for a transparent screening and inclusion/exclusion of studies. All
studies will be sent to RefWorks, and abstraction will be independently performed
by two researchers. Risk of bias will be assessed using Cochrane Risk of Bias
tool for randomized controlled trials, Newcastle-Ottawa Quality Assessment Scale
for non-randomized studies, and for case reports, Murad et al. tool will be used.
Decision to conduct meta-analysis will be based on several factors including
homogeneity and outcome measures reported; otherwise, a narrative synthesis will
be deemed appropriate. DISCUSSION: This systematic review will summarize the
existing data on effect of COVID-19 on maternal and perinatal population.
Furthermore, to the best of our knowledge, this is the first systematic review
addressing therapeutic management and safety of medicines to treat COVID-19
during pregnancy and breastfeeding. SYSTEMATIC REVIEW REGISTRATION: This
systematic review has been registered and published with Prospero (
CRD42020172773 ).
free
free
free
