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10.1016/j.cmet.2020.07.007 http://scihub22266oqcxt.onion/10.1016/j.cmet.2020.07.007 C7367032!7367032 !32697943     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32697943 &cmd=llinks): Failed to open stream: HTTP request failed! 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Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1?/Glycolysis-Dependent Axis |pdf=|usr=}}{{32697943 }} gab.com Text Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1 /Glycolysis-Dependent Axis JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=32697943 #FOAvip COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication. The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1? (HIF-1?) and consequently promotes glycolysis. HIF-1?-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival. Targeting HIF-1? may have great therapeutic potential for the development of novel drugs to treat COVID-19. Twit Text FOAVip Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1 /Glycolysis-Dependent Axis ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=32697943 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32697943 #FOAvip English Wikipedia <ref>{{Cite pmid|32697943 }}</ref> Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1?/Glycolysis-Dependent Axis #MMPMID32697943 Codo AC ; Davanzo GG ; Monteiro LB ; de Souza GF ; Muraro SP ; Virgilio-da-Silva JV ; Prodonoff JS ; Carregari VC ; de Biagi Junior CAO ; Crunfli F ; Jimenez Restrepo JL ; Vendramini PH ; Reis-de-Oliveira G ; Bispo Dos Santos K ; Toledo-Teixeira DA ; Parise PL ; Martini MC ; Marques RE ; Carmo HR ; Borin A ; Coimbra LD ; Boldrini VO ; Brunetti NS ; Vieira AS ; Mansour E ; Ulaf RG ; Bernardes AF ; Nunes TA ; Ribeiro LC ; Palma AC ; Agrela MV ; Moretti ML ; Sposito AC ; Pereira FB ; Velloso LA ; Vinolo MAR ; Damasio A ; Proença-Módena JL ; Carvalho RF ; Mori MA ; Martins-de-Souza D ; Nakaya HI ; Farias AS ; Moraes-Vieira PM Cell Metab 2020[Sep]; 32 (3 ): 437-446.e5 PMID32697943 show ga COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication. The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1? (HIF-1?) and consequently promotes glycolysis. HIF-1?-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival. Targeting HIF-1? may have great therapeutic potential for the development of novel drugs to treat COVID-19. |Adult [MESH] |Betacoronavirus/*physiology [MESH] |Blood Glucose/*metabolism [MESH] |COVID-19 [MESH] |Cell Line [MESH] |Coronavirus Infections/*complications/metabolism [MESH] |Diabetes Complications/*complications/metabolism [MESH] |Diabetes Mellitus/metabolism [MESH] |Female [MESH] |Glycolysis [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism [MESH] |Inflammation/complications/metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Monocytes/*metabolism/virology [MESH] |Pandemics [MESH] |Pneumonia, Viral/*complications/metabolism [MESH] |Reactive Oxygen Species/metabolism [MESH] |SARS-CoV-2 [MESH]Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Respon(epmc).pdf DeepDyve Pubget Overpricing