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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Infect+Public+Health
2020 ; 13
(9
): 1202-1209
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Epidemiological and clinical characteristics of 1663 hospitalized patients
infected with COVID-19 in Wuhan, China: a single-center experience
#MMPMID32718894
Yu C
; Lei Q
; Li W
; Wang X
; Li W
; Liu W
J Infect Public Health
2020[Sep]; 13
(9
): 1202-1209
PMID32718894
show ga
BACKGROUND: The COVID-19 outbreak in late December 2019 has quickly emerged into
pandemic in 2020. We aimed to describe the epidemiology and clinical
characteristics of hospitalized COVID-19 patients, and to investigate the
potential risk factors for COVID-19 severity. METHOD: 1663 hospitalized patients
with laboratory-confirmed diagnosed COVID-19 from Tongji Hospital between January
14, 2020, and February 28, 2020 were included in the present study. Demographic
information, exposure history, medical history, comorbidities, signs and
symptoms, chest computed tomography (CT) scanning, severity of COVID-19 and
laboratory findings on admission were collected from electronic medical records.
Multivariable logistic regression was used to explore the association between
potential risk factors with COVID-19 severity. RESULTS: In the present study, the
majority (79%) of 1663 COVID-19 patients were aged over 50 years old. A total of
2.8% were medical staff, and an exposure history of Huanan seafood market was
document in 0.7%, and 7.4% were family infection. Fever (85.8%), cough (36.0%),
fatigue (23.6%) and chest tightness (11.9%) were the most common symptoms in
COVID-19 patients. As of February 28, 2020, of the 1663 patients included in this
study, 26.0% were discharged, 10.2% were died, and 63.8% remained hospitalized.
More than 1/3 of the patients had at least one comorbidity. Most (99.8%) patients
had abnormal results Chest CT, and the most common manifestations of chest CT
were local patchy shadowing (70.7%) and ground-glass opacity (44.8%). On
admission, lymphocytopenia was present in 51.1% of the patients, mononucleosis in
26.6%, and erythrocytopenia in 61.3%. Most of the patients had increased levels
of C-reactive protein (80.4%) and D-dimer (64.4%). Compared with non-severe
patients, severe patients had more obvious abnormal laboratory results related to
inflammation, coagulation disorders, liver and kidney damage (all P < 0.05).
Older age (OR = 2.37, 95% CI: 1.47-3.83), leukocytosis (OR = 2.37, 95% CI:
1.47-3.83), and increased creatine kinase (OR = 2.37, 95% CI: 1.47-3.83) on
admission were significantly associated with COVID-19 severity. CONCLUSION:
Timely medical treatment and clear diagnosis after the onset might be beneficial
to control the condition of COVID-19. Severe patients were more likely to be to
be elder, and tended to have higher proportion of comorbidities and more
prominent laboratory abnormalities. Older age, leukocytosis, and increased
creatine kinase might help clinicians to identify severe patients with COVID-19.