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10.1016/j.arr.2020.101123 http://scihub22266oqcxt.onion/10.1016/j.arr.2020.101123 C7365123!7365123 !32683039     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32683039 &cmd=llinks): Failed to open stream: HTTP request failed! 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ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis |pdf=|usr=}}{{32683039 }} gab.com Text ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis JO: Ageing Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=32683039 #FOAvip Coronavirus disease 19 (COVID-19) is a pandemic condition caused by the new coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath, evolving to a clinical picture of pneumonia and, ultimately, death. Nausea and diarrhea are equally frequent, suggesting viral infection or transmission via the gastrointestinal-enteric system. SARS-CoV-2 infects human cells by using angiotensin converting enzyme 2 (ACE2) as a receptor, which is cleaved by transmembrane proteases during host cells infection, thus reducing its activities. ACE2 is a relevant player in the renin-angiotensin system (RAS), counterbalancing the deleterious effects of angiotensin II. Furthermore, intestinal ACE2 functions as a chaperone for the aminoacid transporter B(0)AT1. It has been suggested that B(0)AT1/ACE2 complex in the intestinal epithelium regulates gut microbiota (GM) composition and function, with important repercussions on local and systemic immune responses against pathogenic agents, namely virus. Notably, productive infection of SARS-CoV-2 in ACE2(+) mature human enterocytes and patients' GM dysbiosis was recently demonstrated. This review outlines the evidence linking abnormal ACE2 functions with the poor outcomes (higher disease severity and mortality rate) in COVID-19 patients with pre-existing age-related comorbidities and addresses a possible role for GM dysbiosis. The article culminates with the therapeutics opportunities based on these pathways. Twit Text FOAVip ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis ????Ageing Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=32683039 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32683039 #FOAvip English Wikipedia <ref>{{Cite pmid|32683039 }}</ref> ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis #MMPMID32683039 Viana SD ; Nunes S ; Reis F Ageing Res Rev 2020[Sep]; 62 (ä): 101123 PMID32683039 show ga Coronavirus disease 19 (COVID-19) is a pandemic condition caused by the new coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath, evolving to a clinical picture of pneumonia and, ultimately, death. Nausea and diarrhea are equally frequent, suggesting viral infection or transmission via the gastrointestinal-enteric system. SARS-CoV-2 infects human cells by using angiotensin converting enzyme 2 (ACE2) as a receptor, which is cleaved by transmembrane proteases during host cells infection, thus reducing its activities. ACE2 is a relevant player in the renin-angiotensin system (RAS), counterbalancing the deleterious effects of angiotensin II. Furthermore, intestinal ACE2 functions as a chaperone for the aminoacid transporter B(0)AT1. It has been suggested that B(0)AT1/ACE2 complex in the intestinal epithelium regulates gut microbiota (GM) composition and function, with important repercussions on local and systemic immune responses against pathogenic agents, namely virus. Notably, productive infection of SARS-CoV-2 in ACE2(+) mature human enterocytes and patients' GM dysbiosis was recently demonstrated. This review outlines the evidence linking abnormal ACE2 functions with the poor outcomes (higher disease severity and mortality rate) in COVID-19 patients with pre-existing age-related comorbidities and addresses a possible role for GM dysbiosis. The article culminates with the therapeutics opportunities based on these pathways. |*Gastrointestinal Microbiome [MESH] |Angiotensin-Converting Enzyme 2 [MESH] |Betacoronavirus/*metabolism [MESH] |COVID-19 [MESH] |Comorbidity [MESH] |Coronavirus Infections/complications/enzymology/*microbiology/therapy [MESH] |Dysbiosis/*virology [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH] |Pandemics [MESH] |Peptidyl-Dipeptidase A/*metabolism [MESH] |Pneumonia, Viral/complications/enzymology/*microbiology/therapy [MESH] |Receptor Cross-Talk [MESH] |Renin-Angiotensin System [MESH]ACE2 imbalance as a key player for the poor outcomes in COVID-19 patie(epmc).pdf DeepDyve Pubget Overpricing