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2020 ; 20
(1
): 519
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Correlation analysis between disease severity and clinical and biochemical
characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study
#MMPMID32677918
Wang D
; Li R
; Wang J
; Jiang Q
; Gao C
; Yang J
; Ge L
; Hu Q
BMC Infect Dis
2020[Jul]; 20
(1
): 519
PMID32677918
show ga
BACKGROUND: Coronavirus disease 2019 (COVID-19) is a novel infectious disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged in Wuhan and has quickly spread across the world. The mortality rate in
critically ill patients with COVID-19 is high. This study analyzed clinical and
biochemical parameters between mild and severe patients, helping to identify
severe or critical patients early. METHODS: In this single center,
cross-sectional study, 143 patients were included and divided to mild/moderate
and sever/critical groups. Correlation between the disease criticality and
clinical features and peripheral blood biochemical markers was analyzed. Cut-off
values for critically ill patients were speculated through the ROC curve.
RESULTS: Significantly, disease severity was associated with age (r?=?0.458,
P?0.001), comorbidities (r?=?0.445, P?0.001), white cell count (r?=?0.229,
P?=?0.006), neutrophil count (r?=?0.238, P?=?0.004), lymphocyte count
(r?=?-?0.295, P?0.001), albumin (r?=?-?0.603, P?0.001), high-density
lipoprotein cholesterol (r?=?-?0.362, P?0.001), serum potassium (r?=?-?0.237,
P?=?0.004), plasma glucose (r?=?0.383, P?0.001), total bilirubin (r?=?0.340,
P?0.001), serum amyloid A (r?=?0.58, P?0.001), procalcitonin (r?=?0.345,
P?0.001), C-reactive protein (r?=?0.477, P?0.001), lactate dehydrogenase
(r?=?0.548, P?0.001), aspartate aminotransferase (r?=?0.342, P?0.001),
alanine aminotransferase (r?=?0.264, P?=?0.001), erythrocyte sedimentation rate
(r?=?0.284, P?=?0.001) and D-dimer (r?=?0.477, P < 0.001) . CONCLUSIONS: With the
following parameters such as age?>?52?years, C-reactive protein >?64.79?mg/L,
lactate dehydrogenase >?245?U/L, D-dimer >?0.96 ?g/mL, serum amyloid
A?>?100.02?mg/L, or albumin < 36?g/L, the progress of COVID-19 to critical stage
should be closely observed and possibly prevented. Lymphocyte count, serum
potassium, high-density lipoprotein cholesterol and procalcitonin may also be a
prognostic indicator.