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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Reprod+Infertil
2020 ; 21
(3
): 157-168
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the
Possibility of Vertical Transmission
#MMPMID32685412
Ashraf MA
; Keshavarz P
; Hosseinpour P
; Erfani A
; Roshanshad A
; Pourdast A
; Nowrouzi-Sohrabi P
; Chaichian S
; Poordast T
J Reprod Infertil
2020[Jul]; 21
(3
): 157-168
PMID32685412
show ga
BACKGROUND: There is a growing need for information regarding maternal and
neonatal outcomes during coronavirus pandemic. In this study, a comprehensive
investigation was done regarding the possibility of vertical transmission using
the available data in the literature. METHODS: A systematic search was conducted
using electronic databases, including PubMed, Scopus, Web of Science, Embase, and
Scholar. All studies containing infected COVID-19 pregnant women who had given
birth were included, and the search was done up to April 14, 2020. RESULTS:
Overall, 21 articles were reviewed, and clinical characteristics of 90 pregnant
patients and 92 neonates born to mothers infected with COVID-19 were reviewed.
The most common symptoms included fever, cough, and dyspnea. The main laboratory
findings included leukocytosis, lymphopenia, thrombocytopenia, and elevated
C-reactive protein. The most commonly reported complications were preterm labor
and fetal distress. Three mothers were admitted to ICU and required mechanical
ventilation; among them, one died, and one was on extracorporeal membrane
oxygenation. Overall, 86 neonates were tested for the possibility of vertical
transmission and 82 cases were negative in RT-PCR, while 4 were positive. Out of
92 neonates, one died, and one was born dead. Nineteen patients reported having
no symptoms, while breathing problems and pneumonia were reported as the most
common neonatal complications. CONCLUSION: There were no differences in the
clinical characteristics of pregnant women and non-pregnant COVID-19 patients.
COVID-19 infection has caused higher incidence of fetal distress and premature
labor in pregnant women. Although the possibility of vertical transmission in
infected pregnant women is rare, four neonates' test results for COVID-19
infection were positive in this review.